One in three health workers suffering āburnoutā amid NHS staffing crisis
...high blood pressure, chest pains and headaches are among the physical signs of stress reported by nurses, porters, 999 call handlers and other NHS staff who completed the survey.
Had a woman in 70s whose vascular stunned by fastest progression ever seen in her carotids. And dozens of stents and pacemakers in 2022-23! Normal year pre jab 1-2 pacemakers annually in primary geriatric care.
"Atherosclerotic lesions which have progressed during this period are unlikely to regress back to the starting condition, at least without strong meds throughout as a prophylactic."
What is the method of regression?
Preventing progression is well and good, but aside from the serapeptide research, I haven't yet been informed of any substance with a verifiably direct mechanism of action for reversing plaque accrual within endothelial strata.
Always ready to update my priors if there's something I've missed.
Partial regression is relatively easy, but significant Glagovian atheroregression is much more challenging, partly due to necrosis & calcification with lack of vasculature.
Slowing progression is a goal in itself though.
Here are some more BSTs, including Nigella and lots of Salvia:
Medicinal Herbs Effective Against Atherosclerosis: Classification According to Mechanism of Action (2019)
Had a very interesting discussion with a cardiologist, a few months ago. His observation about Carvedilol was surprising to me. His assertion was that its anti-inflammatory properties provided it with a place in the anti-arteriosclerosis regimen regardless of the absence of hypertension.
With K2 demonstrating a nontrivial role in metabolizing calcium and serrapeptase having a verifiable mechanism of action, it seems that the "wild card" becomes the destabilization of plaques.
What has been of abiding interest has been the interesting inversion of mortality risk at five years post-STEMI revealed in studies such as the ISCHEMIA trial.
I have an utterly unsupported and ignorant theory, based on my own experience of a 100% LAD arterial blockage resulting in acute cardiogenic shock. It is that the lower mortality associated with denial of revascularization is plausibly owing to the debilitating effects of the medications prescribed. If one is too weak, myalgic and dizzy to move, the likelihood of over-exertion is greatly reduced.
Today's article, by the way, is one that I will re-read when more alert. It's rich in detail, well-supported and highly informative. Thank you for all of the time and effort you invested.
Thank you Ted for your feedback. Interesting about Carvedilol and its a good example of the benefits of reduction of immune activation Vs BP reduction as a target.
Spot on about K2, it is apparently unique due to Matrix Gla Protein (MGP) activation. I think it can regress Ca buildup to a point, based on my reading years ago but need to refind the studies.
Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review
Important point too: one of the paradoxes is that once you find a drug potent enough to work it can kill you! They found this in attempts to reverse cardiac remodelling due to the associated immune response.
And did you see my work on synthetic mRNA & primRNAs leading to miR-21? We have a natural circadian growth and regression cycle. The circadian rhythm is disrupted and plaque instability in the early hours can result.
I hadn't seen your work on miR-21, but I will review it with great interest.
I also hadn't understood the role of beta-andrenergics in neurohormonal blockade as a controlling factor. It opens the door to some interesting reading:
"Whether beta-adrenergic blockers also prevent adverse ventricular remodeling is controversial, and systematic use of higher doses of beta-adrenergic blockers during MI increases the risk of hypotension and cardiogenic shock."
I don't want to impose on your generosity, but your reference to the efficacy paradox regarding cardiac remodeling is intriguing and if you have the time to refer me to a source that distills the current state of understanding, a link would be greatly appreciated. You will have already discerned that my interest is not purely academic.
"There is so much to consider."
A simple phrase, that, and yet so evocative. It captures the zeitgeist of our times without prejudice. Ironic how seldom we hear it.
Good to see baicalin in this list, along with other TCM therapeutics that have been used for generations and Western medicine is still playing catch up:
Promising Therapeutic Treatments for Cardiac Fibrosis: Herbal Plants and Their Extracts (2023)
Thank you so much - I had previously seen Dr. Peter McCulloghās mention of advancement of atherosclerosis in a speech last September to the EU. Your article expounds expertly in the subject which Iām sure is not going to be readily received or examined by the present contingent of cardiologistsā¦ā¦ā¦
Another outstanding list of broad spectrum therapeutics...added verbatim to my notes. TYVM DC.
Suggestions:
Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained fromĀ Larrea tridentata, the creosote bush found in Mexico and US deserts, that has been used in traditional medicine for the treatment of numerous diseases such as cancer; and renal, cardiovascular, immunological, and neurological disorders; and even aging...NDGA presents two catechol rings that confer a very potent antioxidant activity by scavenging oxygen free radicals, and this may explain part of its therapeutic action. Additional effects include inhibition of lipoxygenases (LOXs), and activation of signaling pathways that impinge on the transcription factor Nuclear Factor Erythroid 2-related Factor (NRF2).
Plant Polyphenols Structurally Related to Resveratrol: The natural polyphenols which activate sirtuins include the stilbeneĀ piceatannol, the chalcones butein and isoliquiritigenin, and the flavonesĀ fisetinĀ andĀ quercetin.Ā These compounds activated human SIRT1 deacetylase activity 4ā8-folds (under conditions where a 13-fold activation withĀ RVĀ was observed) and extended lifespan inĀ S. cerevisiae. These compounds also activatedĀ sirtuinĀ deacetylase activity inĀ D. melanogasterĀ S2 cells, and presented 25% lifspan extension when flies were fed with 100Ā Ī¼M fisetin, similar to the 29% extension observed with RV.
Wow, another wonderful and detailed breakdown- I just love sitting down and trying to get through it all and then marinating on it. I will post it on my tiny twitter account :)
This language was particularly concerning ā Figure 5. Interaction propensity of lncRNAs involved in pulmonary arterial hypertension, antiviral response, and inflammatory diseasesā, I mean that is a LOT of things to worry about and to add to elevated IgG4, amyloid plaques, myocarditis,and now aortic aneurysms (aka the widow makers)!
A dear friend of mine who is only a little overweight, does half triathlons regularly and just ran half a marathon, suffers from high blood pressure and Iāve been re-reading your earlier article on it to go over his possible routes. He wants to get off of the medicines, he was put on olmesartan medoxomil at 40mg, hydrochlorothiazide 12.5mg, and rosuvastatin calcium 5 mg. He also has low iron which I pointed out could mean he has a gluten intolerance (it was the sign of my sonā celiac). I also heard that statins can lead to glucose intolerance which then leads to diabetes and then your medicines get only more complicated! Iām focusing on his diet and trying to get him to start with something simple to follow, like meat (with very little flavoring) and a side of steamed veggies. Little to no sugar and hyper reduced carbs, maybe just baked potatoes on occasion. Breakfast can be eggs, or better yet would be intermittent fasting if he were to take a break from running to focus solely on his high blood pressure.
Also, at the beginning you were mentioning that Sweden might have lower excess mortality due to better health from itās inhabitants, but I noticed that oddly enough, Norway has a very high excess mortality even though it shares many factors with Sweden, climate, diet, health, etc, so now Iām looking again to see if it has to do with Astra Zeneca being used predominantly in the beginning in Sweden (later that was dropped) where I believe Norway waited for Pfizer???
To help your friend, get them to read the book Eat Rich, Live Long by Ivor Cummins and Jeffry Gerber which explains how hyperinsulinaemia is a root cause for hypertension & diabetes etc. Ivor also has a website thefatemperor.com and many videos on YouTube. Ivor is very vocal about covid tyranny and the ensuing world tyranny, so if your friend is not āone of usā then maybe just get them the book!
Thank you for the amount of time it took to compile this. As usual, I will need to go through it several more times. I did spot 2 names of those I rank as highly despicable: Baric & Hotez
Thank you Dr. Linda. Indeed, and I'm blocked by one of them (like most of us). He is willing to promote the technology but never to discuss it. Running away is the answer...
Thank you Geoff for your comments and links. LPS is in the literature as a co-factor and it could fill several more Substacks & papers on it's own, which is your specialism.
It would be interesting if the experimental.observations were solely due to contamination or whether pure Spike does the same. I suspect it does but the commercial batches are worse still.
Gaslighting themselves?
One in three health workers suffering āburnoutā amid NHS staffing crisis
...high blood pressure, chest pains and headaches are among the physical signs of stress reported by nurses, porters, 999 call handlers and other NHS staff who completed the survey.
https://www.msn.com/en-gb/health/other/one-in-three-health-workers-suffering-burnout-amid-nhs-staffing-crisis/ar-BB1lgvuJ
Background:
Vaccination as a condition of deployment (VCOD) for healthcare workers: frequently asked questions
https://www.england.nhs.uk/coronavirus/documents/vaccination-as-a-condition-of-deployment-vcod-for-healthcare-workers-frequently-asked-questions/
Agree with your 4 ways spike can penetrate endothelium and leucocytes. Also fenestrated epithelium allows for organ exposure to LNPs, spike etc
Had a woman in 70s whose vascular stunned by fastest progression ever seen in her carotids. And dozens of stents and pacemakers in 2022-23! Normal year pre jab 1-2 pacemakers annually in primary geriatric care.
Frightening.
And sadly, mortality follows morbidity.
"Atherosclerotic lesions which have progressed during this period are unlikely to regress back to the starting condition, at least without strong meds throughout as a prophylactic."
What is the method of regression?
Preventing progression is well and good, but aside from the serapeptide research, I haven't yet been informed of any substance with a verifiably direct mechanism of action for reversing plaque accrual within endothelial strata.
Always ready to update my priors if there's something I've missed.
Partial regression is relatively easy, but significant Glagovian atheroregression is much more challenging, partly due to necrosis & calcification with lack of vasculature.
Slowing progression is a goal in itself though.
Here are some more BSTs, including Nigella and lots of Salvia:
Medicinal Herbs Effective Against Atherosclerosis: Classification According to Mechanism of Action (2019)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513182/
Many thanks, I will review the link closely.
Had a very interesting discussion with a cardiologist, a few months ago. His observation about Carvedilol was surprising to me. His assertion was that its anti-inflammatory properties provided it with a place in the anti-arteriosclerosis regimen regardless of the absence of hypertension.
With K2 demonstrating a nontrivial role in metabolizing calcium and serrapeptase having a verifiable mechanism of action, it seems that the "wild card" becomes the destabilization of plaques.
What has been of abiding interest has been the interesting inversion of mortality risk at five years post-STEMI revealed in studies such as the ISCHEMIA trial.
I have an utterly unsupported and ignorant theory, based on my own experience of a 100% LAD arterial blockage resulting in acute cardiogenic shock. It is that the lower mortality associated with denial of revascularization is plausibly owing to the debilitating effects of the medications prescribed. If one is too weak, myalgic and dizzy to move, the likelihood of over-exertion is greatly reduced.
Today's article, by the way, is one that I will re-read when more alert. It's rich in detail, well-supported and highly informative. Thank you for all of the time and effort you invested.
Thank you Ted for your feedback. Interesting about Carvedilol and its a good example of the benefits of reduction of immune activation Vs BP reduction as a target.
Spot on about K2, it is apparently unique due to Matrix Gla Protein (MGP) activation. I think it can regress Ca buildup to a point, based on my reading years ago but need to refind the studies.
Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387246/
Important point too: one of the paradoxes is that once you find a drug potent enough to work it can kill you! They found this in attempts to reverse cardiac remodelling due to the associated immune response.
And did you see my work on synthetic mRNA & primRNAs leading to miR-21? We have a natural circadian growth and regression cycle. The circadian rhythm is disrupted and plaque instability in the early hours can result.
https://doorlesscarp953.substack.com/p/microrna-mir-21-cancer-and-circadian
There is so much to consider.
I hadn't seen your work on miR-21, but I will review it with great interest.
I also hadn't understood the role of beta-andrenergics in neurohormonal blockade as a controlling factor. It opens the door to some interesting reading:
"Whether beta-adrenergic blockers also prevent adverse ventricular remodeling is controversial, and systematic use of higher doses of beta-adrenergic blockers during MI increases the risk of hypotension and cardiogenic shock."
(https://www.acc.org/latest-in-cardiology/articles/2016/07/21/07/28/causes-and-prevention-of-ventricular-remodeling-after-mi)
Which, I think, may be to your point.
I don't want to impose on your generosity, but your reference to the efficacy paradox regarding cardiac remodeling is intriguing and if you have the time to refer me to a source that distills the current state of understanding, a link would be greatly appreciated. You will have already discerned that my interest is not purely academic.
"There is so much to consider."
A simple phrase, that, and yet so evocative. It captures the zeitgeist of our times without prejudice. Ironic how seldom we hear it.
I have rediscovered a paper with a great summary of the challenge, and saved it to my repository along with the TCM papers.
Can Myocardial Fibrosis Be Reversed? (2019)
https://www.jacc.org/doi/10.1016/j.jacc.2018.10.094
Good to see baicalin in this list, along with other TCM therapeutics that have been used for generations and Western medicine is still playing catch up:
Promising Therapeutic Treatments for Cardiac Fibrosis: Herbal Plants and Their Extracts (2023)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423196/
This is a useful review:
Traditional Chinese medicine as a therapeutic option for cardiac fibrosis: Pharmacology and mechanisms (2021)
https://www.sciencedirect.com/science/article/pii/S0753332221007617
Thank you so much - I had previously seen Dr. Peter McCulloghās mention of advancement of atherosclerosis in a speech last September to the EU. Your article expounds expertly in the subject which Iām sure is not going to be readily received or examined by the present contingent of cardiologistsā¦ā¦ā¦
Your work is greatly appreciated.
Thank you Nan, this is a case where I would wish to be proven wrong in the long run!
Another outstanding list of broad spectrum therapeutics...added verbatim to my notes. TYVM DC.
Suggestions:
Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained fromĀ Larrea tridentata, the creosote bush found in Mexico and US deserts, that has been used in traditional medicine for the treatment of numerous diseases such as cancer; and renal, cardiovascular, immunological, and neurological disorders; and even aging...NDGA presents two catechol rings that confer a very potent antioxidant activity by scavenging oxygen free radicals, and this may explain part of its therapeutic action. Additional effects include inhibition of lipoxygenases (LOXs), and activation of signaling pathways that impinge on the transcription factor Nuclear Factor Erythroid 2-related Factor (NRF2).
https://pubmed.ncbi.nlm.nih.gov/32184727/
Plant Polyphenols Structurally Related to Resveratrol: The natural polyphenols which activate sirtuins include the stilbeneĀ piceatannol, the chalcones butein and isoliquiritigenin, and the flavonesĀ fisetinĀ andĀ quercetin.Ā These compounds activated human SIRT1 deacetylase activity 4ā8-folds (under conditions where a 13-fold activation withĀ RVĀ was observed) and extended lifespan inĀ S. cerevisiae. These compounds also activatedĀ sirtuinĀ deacetylase activity inĀ D. melanogasterĀ S2 cells, and presented 25% lifspan extension when flies were fed with 100Ā Ī¼M fisetin, similar to the 29% extension observed with RV.
https://www.sciencedirect.com/science/article/pii/B9780128032398000351
Thank you for your additions. Quercetin appears as a constituent in all sorts of different herbs, albeit in varying concentrations.
One of your best yet. An absolute tour de force.
Thank you. Its been an experience!
Wow, another wonderful and detailed breakdown- I just love sitting down and trying to get through it all and then marinating on it. I will post it on my tiny twitter account :)
This language was particularly concerning ā Figure 5. Interaction propensity of lncRNAs involved in pulmonary arterial hypertension, antiviral response, and inflammatory diseasesā, I mean that is a LOT of things to worry about and to add to elevated IgG4, amyloid plaques, myocarditis,and now aortic aneurysms (aka the widow makers)!
A dear friend of mine who is only a little overweight, does half triathlons regularly and just ran half a marathon, suffers from high blood pressure and Iāve been re-reading your earlier article on it to go over his possible routes. He wants to get off of the medicines, he was put on olmesartan medoxomil at 40mg, hydrochlorothiazide 12.5mg, and rosuvastatin calcium 5 mg. He also has low iron which I pointed out could mean he has a gluten intolerance (it was the sign of my sonā celiac). I also heard that statins can lead to glucose intolerance which then leads to diabetes and then your medicines get only more complicated! Iām focusing on his diet and trying to get him to start with something simple to follow, like meat (with very little flavoring) and a side of steamed veggies. Little to no sugar and hyper reduced carbs, maybe just baked potatoes on occasion. Breakfast can be eggs, or better yet would be intermittent fasting if he were to take a break from running to focus solely on his high blood pressure.
Also, at the beginning you were mentioning that Sweden might have lower excess mortality due to better health from itās inhabitants, but I noticed that oddly enough, Norway has a very high excess mortality even though it shares many factors with Sweden, climate, diet, health, etc, so now Iām looking again to see if it has to do with Astra Zeneca being used predominantly in the beginning in Sweden (later that was dropped) where I believe Norway waited for Pfizer???
To help your friend, get them to read the book Eat Rich, Live Long by Ivor Cummins and Jeffry Gerber which explains how hyperinsulinaemia is a root cause for hypertension & diabetes etc. Ivor also has a website thefatemperor.com and many videos on YouTube. Ivor is very vocal about covid tyranny and the ensuing world tyranny, so if your friend is not āone of usā then maybe just get them the book!
Thank you!! Iām ordering it now!
Thank you, your tailored wholistic approach sounds ideal.
Interesting point about Norway and their choices & outcomes... igG4 class switching is not triggered by AZ and may have been a factor.
Thank you for the amount of time it took to compile this. As usual, I will need to go through it several more times. I did spot 2 names of those I rank as highly despicable: Baric & Hotez
Thank you Dr. Linda. Indeed, and I'm blocked by one of them (like most of us). He is willing to promote the technology but never to discuss it. Running away is the answer...
There once was day when running away was not acceptable.
Too true - there once was a day when the nightmare of the last four years was not only unacceptable but also unimaginableā¦ā¦
Very nice. Good to see Endotoxin mentioned once.
Endotoxin upregulates MYD88 so experiments using contaminated commercial Spike are often compromised.
116 line entries from the US government Comparative Toxicogenomics Database on Endotoxin upregulating MYD88 with its downstream impacts
https://ctdbase.org/detail.go?type=gene&acc=4615&view=ixn&chemAcc=D008070
see also
https://geoffpain.substack.com/p/gmo-spike-protein-carries-e-coli
and
https://geoffpain.substack.com/p/sars-cov-2-spike-protein-is-not-pro
We know Endotoxin is present in every vile vial of Covid19 Jab
Thank you Geoff for your comments and links. LPS is in the literature as a co-factor and it could fill several more Substacks & papers on it's own, which is your specialism.
It would be interesting if the experimental.observations were solely due to contamination or whether pure Spike does the same. I suspect it does but the commercial batches are worse still.
The Legal term for LPS is Endotoxin.
https://www.tga.gov.au/products/covid-19/covid-19-vaccines/batch-release-assessment-covid-19-vaccines