Great thread thanks and based on this paper I'm sure. Very relevant this week. Not only can non-classical monocytes persist for 15+ months but they can cause cerebral neurotoxicity in the process.
Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection
"Previously, CD16+ monocytes were demonstrated to migrate into the brain of AIDS patients expressing high levels of CX3CL1 (fractalkine) and SDF-1 (26), and mediate blood-brain barrier damage and neuronal injury in HIV-associated dementia via their release of proinflammatory cytokines and neurotoxic factors. Interestingly, a number of papers have been written discussing the increased mobilization of CD14lo, CD16+ monocytes with exercise (27). These data could help to explain reports of worsening PASC symptoms in individuals resuming pre-COVID exercise regimens."
Re: nicotine
https://archive.4plebs.org/pol/thread/332125809/
Great thread thanks and based on this paper I'm sure. Very relevant this week. Not only can non-classical monocytes persist for 15+ months but they can cause cerebral neurotoxicity in the process.
Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection
"Previously, CD16+ monocytes were demonstrated to migrate into the brain of AIDS patients expressing high levels of CX3CL1 (fractalkine) and SDF-1 (26), and mediate blood-brain barrier damage and neuronal injury in HIV-associated dementia via their release of proinflammatory cytokines and neurotoxic factors. Interestingly, a number of papers have been written discussing the increased mobilization of CD14lo, CD16+ monocytes with exercise (27). These data could help to explain reports of worsening PASC symptoms in individuals resuming pre-COVID exercise regimens."
https://www.frontiersin.org/articles/10.3389/fimmu.2021.746021/full