The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ? (2021)
"... It was initially shown to inhibit nuclear import not only of IN, but also of simian virus SV40 large tumour antigen (T-ag) and other IMPα/ÎČ1- (but not IMPÎČ1-) dependent cargoes, consistent with the idea that IMPα (not IN) is the direct target of ivermectin [34,35]. Subsequent work has confirmed this, with ivermectinâs ability to inhibit the nuclear accumulation of various different host, including NF-kB p65 [37,38] and viral proteins demonstrated in transfected and infected cell systems (see Table 1) [14,34]. Ivermectinâs ability to inhibit binding of IMPα to the viral proteins NS5 and T-ag has also been confirmed in a cellular context using the biomolecular fluorescence complementation technique [11] (Table 1)."
As I understand it these individuals have a genetic mutation (s) in IL1RN that antognises proinflammatory cytokine il-1 production, which is great for surviving cytokine storm.
But, as these individuals are born immune suppressed it leads to a nightmare of nasty infections and cancers.
Ivermectin, zinc, c, d, Mg, baicalin etc are much better alternatives.
***
A Novel Mutation of IL1RN in the Deficiency of Interleukin-1 Receptor Antagonist Syndrome
...Both patients presented with pustular dermatitis resembling generalized pustular psoriasis, recurrent multifocal aseptic osteomyelitis, and elevation in the levels of acute-phase reactants, all of which are features most consistent with the DIRA syndrome. Chronic lung disease was observed in 1 of the patients, and jugular venous thrombosis was observed in the other patient.
Interleukin-1 receptor antagonist: a promising cytokine against human squamous cell carcinomas
...Recent studies have revealed the association of the polymorphisms in IL1RA with an increased risk of squamous cell carcinomas (SCCs), including squamous cell carcinoma of the head and neck (SCCHN), cervical squamous cell carcinoma, cutaneous squamous cell carcinoma (cSCC), esophageal squamous cell carcinoma (ESCC), and bronchus squamous cell carcinoma.
Why the FDA and the VRBPAC did not ask the CTGTAC for their assessment of the risks of mRNA 'vaccines' like they did for the AAV vaccines is a question that needs answering.
Thank you so much for all of your voluminous, stellar research to help cancer patients!!!
Of course, it is hugely difficult for the likes of me to understand this material, but I am going to to read and re-read it.
I am definitely going to share this material with my breast cancer group, and with other people who have cancer. Years ago, when my uncle, a doctor, died of lymphoma, my aunt was convinced that his polio shots had been the causative agents. She even used his library card at the med school's library, to do some research.
Thank you Sally. I think I was gaslighted Iike most of us and underestimated the long term consequences of the disastrous polio vax rollout, even today as the SV40 virus appears to persist at a significant level.
And the link to mesothelioma was a shocking revelation, all those times that asbestos was being blamed!
I wrote previously about viruses and breast cancer. If this information helps at all that would be excellent. Effects of ivermectin on latent viruses, directly or not, needs further investigation.
SV40 promoter nightmare. Spike/ACE EMT is another challenge as we all get reinfected at times. Plenty to think about.
Thanks for this complex Saturday morning read. I canât tell you how much I appreciate you putting this together. When my finances are a little more secure you are on my upgrade list.
IVM helps stop TAG going into the nucleus:
The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ? (2021)
"... It was initially shown to inhibit nuclear import not only of IN, but also of simian virus SV40 large tumour antigen (T-ag) and other IMPα/ÎČ1- (but not IMPÎČ1-) dependent cargoes, consistent with the idea that IMPα (not IN) is the direct target of ivermectin [34,35]. Subsequent work has confirmed this, with ivermectinâs ability to inhibit the nuclear accumulation of various different host, including NF-kB p65 [37,38] and viral proteins demonstrated in transfected and infected cell systems (see Table 1) [14,34]. Ivermectinâs ability to inhibit binding of IMPα to the viral proteins NS5 and T-ag has also been confirmed in a cellular context using the biomolecular fluorescence complementation technique [11] (Table 1)."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577703/
Have you had a chance to read and analyze this? Do you know anyone best suited to describe the impact of this study? Note the sponsors: NIH.
https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae031/7625543?login=false#443509963
I hadn't seen that. Thanks for the heads up.
As I understand it these individuals have a genetic mutation (s) in IL1RN that antognises proinflammatory cytokine il-1 production, which is great for surviving cytokine storm.
But, as these individuals are born immune suppressed it leads to a nightmare of nasty infections and cancers.
Ivermectin, zinc, c, d, Mg, baicalin etc are much better alternatives.
***
A Novel Mutation of IL1RN in the Deficiency of Interleukin-1 Receptor Antagonist Syndrome
...Both patients presented with pustular dermatitis resembling generalized pustular psoriasis, recurrent multifocal aseptic osteomyelitis, and elevation in the levels of acute-phase reactants, all of which are features most consistent with the DIRA syndrome. Chronic lung disease was observed in 1 of the patients, and jugular venous thrombosis was observed in the other patient.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463867/
Interleukin-1 receptor antagonist: a promising cytokine against human squamous cell carcinomas
...Recent studies have revealed the association of the polymorphisms in IL1RA with an increased risk of squamous cell carcinomas (SCCs), including squamous cell carcinoma of the head and neck (SCCHN), cervical squamous cell carcinoma, cutaneous squamous cell carcinoma (cSCC), esophageal squamous cell carcinoma (ESCC), and bronchus squamous cell carcinoma.
https://www.sciencedirect.com/science/article/pii/S2405844023021679
Cyprinus carpio, another capolavoro.
Why the FDA and the VRBPAC did not ask the CTGTAC for their assessment of the risks of mRNA 'vaccines' like they did for the AAV vaccines is a question that needs answering.
Apparently it was too hard for either Pfizer or Moderna to find a backronym for "HUBRIS."
Thank you so much for all of your voluminous, stellar research to help cancer patients!!!
Of course, it is hugely difficult for the likes of me to understand this material, but I am going to to read and re-read it.
I am definitely going to share this material with my breast cancer group, and with other people who have cancer. Years ago, when my uncle, a doctor, died of lymphoma, my aunt was convinced that his polio shots had been the causative agents. She even used his library card at the med school's library, to do some research.
Thanks again!!
Thank you Sally. I think I was gaslighted Iike most of us and underestimated the long term consequences of the disastrous polio vax rollout, even today as the SV40 virus appears to persist at a significant level.
And the link to mesothelioma was a shocking revelation, all those times that asbestos was being blamed!
I wrote previously about viruses and breast cancer. If this information helps at all that would be excellent. Effects of ivermectin on latent viruses, directly or not, needs further investigation.
SV40 promoter nightmare. Spike/ACE EMT is another challenge as we all get reinfected at times. Plenty to think about.
Thanks for this complex Saturday morning read. I canât tell you how much I appreciate you putting this together. When my finances are a little more secure you are on my upgrade list.
Thank you Dr. for your kind comments and support.
Just say no.
Every single time!