...Coffee plays a dominant role in that regard because it is the major dietary source of phenolic acids and polyphenols in the developed world. A possible supportive action may be the modulation of the gut microbiota by non-digested prebiotic constituents of coffee, but the available data are still scarce. We conclude that coffee employs similar pathways of promoting health as assumed for other vegetables and fruits. Coffee beans may be viewed as healthy vegetable food and a main supplier of dietary phenolic phytochemicals.
Many thanks for your article, very informative. What we don't know and even worse, what we don't know what we don't know....
I found this paper interesting, especially as I was struggling with problems after being infected with "Cryptosporidium" a rather nasty parasitic bowel infection. (Memo to self, never ever eat raw raspberries, ever).
Very much appreciate your work on this! There are so many different products out there - this has been quite helpful and I will pass on to a relative who had CRC w/surg/chemo... left with neuropathy which his oncologist claimed he hadn't really seen in patients............. right.
I recently heard a dr say that the old 5 to 10 yr rate of CRC development is not valid - said he has seen clean colons and then within 1-2 yrs, CRC is there. Even an oddball one that developed in 6 months. This was trending prior to covid.
I must be missing something as I don't quite understand how those microbes can be effective if they die off at room temp when our bodies are much warmer.
Sauerkraut didn't get a mention - horse of a different color?
I might add this to the cold chain interruption section, it's a good question!
"Considerable loss in viability of probiotics in room temperature could be attributed to increasing cell metabolism and death at higher temperatures (compared to refrigerated storage) as well as to the enhanced antagonistic impact of yogurt bacteria (especially L. delbrueckii ssp. bulgaricus) on probiotic bacteria."
Is it the interaction of the probiotics with other things in the intestinal tract that are what makes it healthy? Because if they die off so easily at body temps I can't figure how the money spent is worth it. If there are very few left alive, how can they do much good?
Hi Sadie, they don't die off that easily and it's the reason why there are billions per dose, even at 50% after 6 hours at room temperature plenty enough go to where they are meant to go. Kefir avoids even this reduction.
Yes I've written about GcMaf in the Cancer Therapeutics Substack, linked in the further reading.
Absolutely, we are in the age of turbo cancers and you will always get cancers that unfortunately progress much faster than the average, but it's worth noting thanks.
I would love to list the many foods that are great for our microbiota and fermented foods other than kefir all have their place. Sauerkraut is a great one!
If you start looking you can find many many others, often with research behind them:
Microbiome analysis of thai traditional fermented soybeans reveals short-chain fatty acid-associated bacterial taxa
Effect of the Short-Term Use of Fluoroquinolone and β-Lactam Antibiotics on Mouse Gut Microbiota
Conclusion
Short-term antibiotic treatment led to significant changes in the intestinal flora with a tendency to recover. The antibiotics had different effects on the intestinal microbial community and probiotic strains. This study provides guidance for the concomitant use of probiotics and antibiotics, and the results emphasize the importance of using broad-spectrum antibiotics responsibly to prevent the long-term disruption of the native microbiota.
Health Effects of Coffee: Mechanism Unraveled?
...Coffee plays a dominant role in that regard because it is the major dietary source of phenolic acids and polyphenols in the developed world. A possible supportive action may be the modulation of the gut microbiota by non-digested prebiotic constituents of coffee, but the available data are still scarce. We conclude that coffee employs similar pathways of promoting health as assumed for other vegetables and fruits. Coffee beans may be viewed as healthy vegetable food and a main supplier of dietary phenolic phytochemicals.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353358/
Well thank goodness for this lol
Many thanks for your article, very informative. What we don't know and even worse, what we don't know what we don't know....
I found this paper interesting, especially as I was struggling with problems after being infected with "Cryptosporidium" a rather nasty parasitic bowel infection. (Memo to self, never ever eat raw raspberries, ever).
https://hal.inrae.fr/hal-03871552/document
The theory and results seems sound and I embarked on a course of "Symbiotics"- a blend of pro and pre biotics.
Without wishing to tempt providence it's working for me....
Also this paper, useful for budding alcoholics -
https://www.mdpi.com/1422-0067/20/18/4568
Thanks! Two very interesting papers there I need to read through.
I'm not that keen on raw raspberries but had no idea😳
Very much appreciate your work on this! There are so many different products out there - this has been quite helpful and I will pass on to a relative who had CRC w/surg/chemo... left with neuropathy which his oncologist claimed he hadn't really seen in patients............. right.
I recently heard a dr say that the old 5 to 10 yr rate of CRC development is not valid - said he has seen clean colons and then within 1-2 yrs, CRC is there. Even an oddball one that developed in 6 months. This was trending prior to covid.
I must be missing something as I don't quite understand how those microbes can be effective if they die off at room temp when our bodies are much warmer.
Sauerkraut didn't get a mention - horse of a different color?
I might add this to the cold chain interruption section, it's a good question!
"Considerable loss in viability of probiotics in room temperature could be attributed to increasing cell metabolism and death at higher temperatures (compared to refrigerated storage) as well as to the enhanced antagonistic impact of yogurt bacteria (especially L. delbrueckii ssp. bulgaricus) on probiotic bacteria."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813376/
Is it the interaction of the probiotics with other things in the intestinal tract that are what makes it healthy? Because if they die off so easily at body temps I can't figure how the money spent is worth it. If there are very few left alive, how can they do much good?
Also - are you familiar with GcMaf?
Hi Sadie, they don't die off that easily and it's the reason why there are billions per dose, even at 50% after 6 hours at room temperature plenty enough go to where they are meant to go. Kefir avoids even this reduction.
Yes I've written about GcMaf in the Cancer Therapeutics Substack, linked in the further reading.
THANK YOU!... Looks like I'll have a fun time reviewing all that info! I need another 24hrs in a day...
Absolutely, we are in the age of turbo cancers and you will always get cancers that unfortunately progress much faster than the average, but it's worth noting thanks.
I would love to list the many foods that are great for our microbiota and fermented foods other than kefir all have their place. Sauerkraut is a great one!
If you start looking you can find many many others, often with research behind them:
Microbiome analysis of thai traditional fermented soybeans reveals short-chain fatty acid-associated bacterial taxa
https://www.nature.com/articles/s41598-023-34818-0
Characterization of microbiota of naturally fermented sauerkraut by high-throughput sequencing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082884/
Fecal microbiota changes with fermented kimchi intake regulated either formation or advancement of colon adenoma
https://pubmed.ncbi.nlm.nih.gov/33879965/
Some antibiotics are worse for the microbiome than others. The quinolones have to be the worst.
Great review, thanks
Thanks Maria!
Effect of the Short-Term Use of Fluoroquinolone and β-Lactam Antibiotics on Mouse Gut Microbiota
Conclusion
Short-term antibiotic treatment led to significant changes in the intestinal flora with a tendency to recover. The antibiotics had different effects on the intestinal microbial community and probiotic strains. This study provides guidance for the concomitant use of probiotics and antibiotics, and the results emphasize the importance of using broad-spectrum antibiotics responsibly to prevent the long-term disruption of the native microbiota.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762438/
Cyprinus Carpio, a not very good, but excellent tour de force of the littlest things that do the biggest things.
"they don't go through the rigorous testing medicines do"
ROFLMAOPIMP and the rest follows...
Because of the way mRNA vaccines are regulated, we are quite sure that:
the product does not actually contain the ingredients stated on the label
the product contains enough mRNA to have an effect
the mRNA are able to survive long enough to reach every system in your body
9 out of 10 Doctors prefer mRNA vaccines for years of satisfying transfection & revenue to come.
Oh the hypocrisy of our "health service" administered in a large dose 3 times daily🤡
Enjoyed reading that with my first cup of coffee for my Sunday.
Thanks Geoff. I noted the link between lps and brain cancer via the gut-brain axis.
Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice
https://www.nature.com/articles/s41598-019-42286-8