In the endoplasmic reticulum and NOT in the plasma. After the Th2 shift of the treated subjects, the spike protein seems to be channeled directly into the membrane and out of the cell by the Golgi."
Given cellular biology is not my strong point, this statement flew over my head, but it strikes me as the most important one, so could you translate into layman's terms? I also have specific questions relating to it:
What's the difference between the 'endoplasmic reticulum' and the plasma, and why would the location matter?
Why would the spike protein being channelled directly into the membrane matter?
What is the Golgi and what does it do/what is it supposed to do?
Why would the Gogli push the spike protein out of the cell?
Overall, what should be happening here/what isn't happening here?
âThe Golgi apparatus, or Golgi complex, functions as a factory in which proteins received from the ER are further processed and sorted for transport to their eventual destinations: lysosomes, the plasma membrane, or secretion. In addition, as noted earlier, glycolipids and sphingomyelin are synthesized within the Golgi.â https://www.ncbi.nlm.nih.gov/books/NBK9838/
In layman's terms of the protein is to be used within the cell then it is made in the cytosol, whereas proteins made in the rough ER eventually are excreted from the cell and put you at increased of autoimmune disorders.
1) Do you think it's Pfizer etc intention to have the cells excrete spike proteins, hence ER targeting is intentional (rather than accidental)? Based on their oversimplified propaganda, it sounded like they wanted cells to act as spike protein factories, and having the ER 'dump out' spike proteins sounds like it fits the bill.
2) Wouldn't spike protein production inside the cytosol mean the spike protein is never outwardly presenting (and ergo, would never "train" the immune system)?
I ask because if the ER is faulty and that design is intentional, then it would be another nail in the coffin showing Pfizer intended for a fundamentally flawed design.
Sure. Unlike fizer, J&J knew not to develop a vaccine that would act act in reverse by shifting your immune response towards a tolerant, anti-inflammatory cytokine Th2 type.
That's not a comment on it's safety or efficacy in other respects.
What makes some researchers comfortable with interfering with complex processes they have very limited knowledge of? And what made the upper management of the dod and cia green light and promote/coerce the administration of these counter measures? My family, adult son and daughter had the Pfizer shot and misguidedly gave them to my 3 young grandchildren, who are now constantly ill. They and many of their friends never totally recover from their previous infection before they acquire the next.
saRNAs. If, and it's a big IF, they can spread from person to person and then continue to self propagate then this no longer meets any definition of a vaccine or a gene therapy. It's a synthetic virus IMOH.
the saRNAs seem even more evil IMO. They're trying to overtake bodily autonomy for those who would say no to that option. Reminds me of the genetic engineering of the mosquitos.... unintended consequences. They behave as if they're Gods.
"Where is the spike protein produced in BNT162B2?
In the endoplasmic reticulum and NOT in the plasma. After the Th2 shift of the treated subjects, the spike protein seems to be channeled directly into the membrane and out of the cell by the Golgi."
Given cellular biology is not my strong point, this statement flew over my head, but it strikes me as the most important one, so could you translate into layman's terms? I also have specific questions relating to it:
What's the difference between the 'endoplasmic reticulum' and the plasma, and why would the location matter?
Why would the spike protein being channelled directly into the membrane matter?
What is the Golgi and what does it do/what is it supposed to do?
Why would the Gogli push the spike protein out of the cell?
Overall, what should be happening here/what isn't happening here?
âThe Golgi apparatus, or Golgi complex, functions as a factory in which proteins received from the ER are further processed and sorted for transport to their eventual destinations: lysosomes, the plasma membrane, or secretion. In addition, as noted earlier, glycolipids and sphingomyelin are synthesized within the Golgi.â https://www.ncbi.nlm.nih.gov/books/NBK9838/
In layman's terms of the protein is to be used within the cell then it is made in the cytosol, whereas proteins made in the rough ER eventually are excreted from the cell and put you at increased of autoimmune disorders.
Follow up questions, as I'm still learning:
1) Do you think it's Pfizer etc intention to have the cells excrete spike proteins, hence ER targeting is intentional (rather than accidental)? Based on their oversimplified propaganda, it sounded like they wanted cells to act as spike protein factories, and having the ER 'dump out' spike proteins sounds like it fits the bill.
2) Wouldn't spike protein production inside the cytosol mean the spike protein is never outwardly presenting (and ergo, would never "train" the immune system)?
I ask because if the ER is faulty and that design is intentional, then it would be another nail in the coffin showing Pfizer intended for a fundamentally flawed design.
Not being a scientist---could someone please explain the J&J potion of this literature?
Some in my family were given that injection.
Thanks so much.
Sure. Unlike fizer, J&J knew not to develop a vaccine that would act act in reverse by shifting your immune response towards a tolerant, anti-inflammatory cytokine Th2 type.
That's not a comment on it's safety or efficacy in other respects.
Any thoughts on safety?
Thank you.
Very helpful.
Oh, and thank you for all of this digging and compiling
Thank you.
What makes some researchers comfortable with interfering with complex processes they have very limited knowledge of? And what made the upper management of the dod and cia green light and promote/coerce the administration of these counter measures? My family, adult son and daughter had the Pfizer shot and misguidedly gave them to my 3 young grandchildren, who are now constantly ill. They and many of their friends never totally recover from their previous infection before they acquire the next.
Bioweapon
Trying to think of a word worse than 'weapon'. Scary thing is -- they're working on more.... ones that may not come in a needle we can refuse.
saRNAs. If, and it's a big IF, they can spread from person to person and then continue to self propagate then this no longer meets any definition of a vaccine or a gene therapy. It's a synthetic virus IMOH.
the saRNAs seem even more evil IMO. They're trying to overtake bodily autonomy for those who would say no to that option. Reminds me of the genetic engineering of the mosquitos.... unintended consequences. They behave as if they're Gods.