When you mention melatonin "Our data demonstrate that melatonin controls the expression of Bmal1 via PI3K/AKT signaling, and Bmal1 plays critical roles in cellular survival..." it would be really helpful to also write about dosage. Therapeutic dosage is so critical so giving people some guidance would be extremely helpful in real life kind a actionable way. Why? Because very few people bother and most "guidance" printed at back of labels are not good enough.
Thank you. Different people, age groups, co morbidies might need different dosage to reach therapeutic effect. This aspect of "therapeutic dosage" is missing from ALL labels. Also just waiting for the deficiency to show via blood work might not be the optimal approach. Giving people insights how to " monitor" and observe what their body is telling them might also be very helpful
You don't need much melatonin for efficacy, so dosing isn't as simple as it is with other therapeutics. It's quite powerful and WebMD are quite correct in deferring you to a consultant. Bayesian dosing may have a place, but I cannot comment on longer term adjustments.
Brilliant, as usual...though Iâve only recently discovered you. Thank you for these insight, especially regarding miRNA and its role in all of this. It has come to my attention that very few (lay) people and EVEN a good number of HC professionals donât know much, if anything, about miRNA.
I'm on a small, international (non-science) team collecting obit data. Dropping like flies age 0-75 (we don't collect 75+). Astonishing. Can't keep up with the obits. The obit writers can't keep up (we can tell by the quality of the obits). Sudden deaths; sudden and lethal cancers; sudden everything. And shocked/grieving families are gently coerced into asking for donations to pharma-funded "foundations"...
Uh, oh. the CLOCK. I am up all hours struggling with all of this hard, hard science.
I also wanted you to know that I know some one who definitely had a number of small strokes - lacunas- and not one of them was in the morning. Anomalies?Â
 Advice for cancer patients, please. Avoid the jabs. Watch the CLOCK. And what else? Thank you, Jennifer, for the study about polyphenols, and the importance of pomegranate!
Thank you.!!!!!
P.S. In reference to the cartoon, Walter Chesnut was just discussing SADS, and how young people can have the hearts of an old person.Â
Thanks Sally. Regarding the clock and incidents caused by breakaway plaques this doesn't exclude CVAs caused by endothelial rupture, which could happen at any time but may be more likely when you have higher BP during the day.
Here's some good news - pomegranate is so amazing because it and other plants use microRNA to fight the oxidative damage of weather and to fight off nibbling creatures.
This paper is open access and the Tables are loaded with excellent data.
One medication, one treatment goal is the medical approach, while one phytonutrient can affect 1000 genes/or pathways, or more. Add the synergistic benefit of say 400 bioactive nutrients in ginger and you could have up and down regulation of all sorts of functions - also in the data Tables.
"For the first time, we show that polyphenol supplementation at nutritional doses can modulate the expression of miRNA in vivo, and we identified five miRNAs that are commonly modulated by all the polyphenols tested, suggesting that they constitute specific miRNA targets."
When you mention melatonin "Our data demonstrate that melatonin controls the expression of Bmal1 via PI3K/AKT signaling, and Bmal1 plays critical roles in cellular survival..." it would be really helpful to also write about dosage. Therapeutic dosage is so critical so giving people some guidance would be extremely helpful in real life kind a actionable way. Why? Because very few people bother and most "guidance" printed at back of labels are not good enough.
Correct. When I write a full review I always cover dosing, interactions, pharmacokinetics and so on.
Timing is a factor with melatonin, and it can help ameliorate the damage caused by vagus nerve impairment.
WebMD is probably the best ready access guide:
https://www.webmd.com/vitamins/ai/ingredientmono-940/melatonin
Thank you. Different people, age groups, co morbidies might need different dosage to reach therapeutic effect. This aspect of "therapeutic dosage" is missing from ALL labels. Also just waiting for the deficiency to show via blood work might not be the optimal approach. Giving people insights how to " monitor" and observe what their body is telling them might also be very helpful
You don't need much melatonin for efficacy, so dosing isn't as simple as it is with other therapeutics. It's quite powerful and WebMD are quite correct in deferring you to a consultant. Bayesian dosing may have a place, but I cannot comment on longer term adjustments.
Brilliant, as usual...though Iâve only recently discovered you. Thank you for these insight, especially regarding miRNA and its role in all of this. It has come to my attention that very few (lay) people and EVEN a good number of HC professionals donât know much, if anything, about miRNA.
Excellent post, just excellent, thank you!
I'm on a small, international (non-science) team collecting obit data. Dropping like flies age 0-75 (we don't collect 75+). Astonishing. Can't keep up with the obits. The obit writers can't keep up (we can tell by the quality of the obits). Sudden deaths; sudden and lethal cancers; sudden everything. And shocked/grieving families are gently coerced into asking for donations to pharma-funded "foundations"...
As always, Brainy Doorless Carp,THANK YOU!
I know about miRNA and breast cancer as cited below.
https://pubmed.ncbi.nlm.nih.gov/18812439/MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
Uh, oh. the CLOCK. I am up all hours struggling with all of this hard, hard science.
I also wanted you to know that I know some one who definitely had a number of small strokes - lacunas- and not one of them was in the morning. Anomalies?Â
 Advice for cancer patients, please. Avoid the jabs. Watch the CLOCK. And what else? Thank you, Jennifer, for the study about polyphenols, and the importance of pomegranate!
Thank you.!!!!!
P.S. In reference to the cartoon, Walter Chesnut was just discussing SADS, and how young people can have the hearts of an old person.Â
https://rumble.com/v1y5rak-streaming-with-walter-chesnut-sudden-adult-death-syndrome.html
START AT TWENTY-NINE MINUTES
Thanks Sally. Regarding the clock and incidents caused by breakaway plaques this doesn't exclude CVAs caused by endothelial rupture, which could happen at any time but may be more likely when you have higher BP during the day.
DC
nice good news/bad news cartoon.
Here's some good news - pomegranate is so amazing because it and other plants use microRNA to fight the oxidative damage of weather and to fight off nibbling creatures.
This paper is open access and the Tables are loaded with excellent data.
One medication, one treatment goal is the medical approach, while one phytonutrient can affect 1000 genes/or pathways, or more. Add the synergistic benefit of say 400 bioactive nutrients in ginger and you could have up and down regulation of all sorts of functions - also in the data Tables.
Great study: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029837
Terrific study, Jennifer!
"For the first time, we show that polyphenol supplementation at nutritional doses can modulate the expression of miRNA in vivo, and we identified five miRNAs that are commonly modulated by all the polyphenols tested, suggesting that they constitute specific miRNA targets."
Thank you!
I did finish a post about it today.https://denutrients.substack.com/p/microrna-are-the-real-regulators
Thank you Jennifer, I always appreciate links to great papers. Will read that through thoroughly.
DC
A write up about it is on my To Do list. Your review here will be a nice background info link. Happy weekend to you.