Updates: 4th December ‘22: (Effects of melatonin & N1-methylpseudouridine substitution in miR-21). 17th August ‘23: (Contents page added). Contents Background miR-21 T cell exhaustion Circadian rhythms Further discussion about ARNTL (BMAL1) BNT162b2 and adenovirus mRNA vectors
When you mention melatonin "Our data demonstrate that melatonin controls the expression of Bmal1 via PI3K/AKT signaling, and Bmal1 plays critical roles in cellular survival..." it would be really helpful to also write about dosage. Therapeutic dosage is so critical so giving people some guidance would be extremely helpful in real life kind a actionable way. Why? Because very few people bother and most "guidance" printed at back of labels are not good enough.
Brilliant, as usual...though I’ve only recently discovered you. Thank you for these insight, especially regarding miRNA and its role in all of this. It has come to my attention that very few (lay) people and EVEN a good number of HC professionals don’t know much, if anything, about miRNA.
I'm on a small, international (non-science) team collecting obit data. Dropping like flies age 0-75 (we don't collect 75+). Astonishing. Can't keep up with the obits. The obit writers can't keep up (we can tell by the quality of the obits). Sudden deaths; sudden and lethal cancers; sudden everything. And shocked/grieving families are gently coerced into asking for donations to pharma-funded "foundations"...
Uh, oh. the CLOCK. I am up all hours struggling with all of this hard, hard science.
I also wanted you to know that I know some one who definitely had a number of small strokes - lacunas- and not one of them was in the morning. Anomalies?
Advice for cancer patients, please. Avoid the jabs. Watch the CLOCK. And what else? Thank you, Jennifer, for the study about polyphenols, and the importance of pomegranate!
Thank you.!!!!!
P.S. In reference to the cartoon, Walter Chesnut was just discussing SADS, and how young people can have the hearts of an old person.
Here's some good news - pomegranate is so amazing because it and other plants use microRNA to fight the oxidative damage of weather and to fight off nibbling creatures.
This paper is open access and the Tables are loaded with excellent data.
One medication, one treatment goal is the medical approach, while one phytonutrient can affect 1000 genes/or pathways, or more. Add the synergistic benefit of say 400 bioactive nutrients in ginger and you could have up and down regulation of all sorts of functions - also in the data Tables.
When you mention melatonin "Our data demonstrate that melatonin controls the expression of Bmal1 via PI3K/AKT signaling, and Bmal1 plays critical roles in cellular survival..." it would be really helpful to also write about dosage. Therapeutic dosage is so critical so giving people some guidance would be extremely helpful in real life kind a actionable way. Why? Because very few people bother and most "guidance" printed at back of labels are not good enough.
Brilliant, as usual...though I’ve only recently discovered you. Thank you for these insight, especially regarding miRNA and its role in all of this. It has come to my attention that very few (lay) people and EVEN a good number of HC professionals don’t know much, if anything, about miRNA.
Excellent post, just excellent, thank you!
I'm on a small, international (non-science) team collecting obit data. Dropping like flies age 0-75 (we don't collect 75+). Astonishing. Can't keep up with the obits. The obit writers can't keep up (we can tell by the quality of the obits). Sudden deaths; sudden and lethal cancers; sudden everything. And shocked/grieving families are gently coerced into asking for donations to pharma-funded "foundations"...
As always, Brainy Doorless Carp,THANK YOU!
I know about miRNA and breast cancer as cited below.
https://pubmed.ncbi.nlm.nih.gov/18812439/MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
Uh, oh. the CLOCK. I am up all hours struggling with all of this hard, hard science.
I also wanted you to know that I know some one who definitely had a number of small strokes - lacunas- and not one of them was in the morning. Anomalies?
Advice for cancer patients, please. Avoid the jabs. Watch the CLOCK. And what else? Thank you, Jennifer, for the study about polyphenols, and the importance of pomegranate!
Thank you.!!!!!
P.S. In reference to the cartoon, Walter Chesnut was just discussing SADS, and how young people can have the hearts of an old person.
https://rumble.com/v1y5rak-streaming-with-walter-chesnut-sudden-adult-death-syndrome.html
START AT TWENTY-NINE MINUTES
nice good news/bad news cartoon.
Here's some good news - pomegranate is so amazing because it and other plants use microRNA to fight the oxidative damage of weather and to fight off nibbling creatures.
This paper is open access and the Tables are loaded with excellent data.
One medication, one treatment goal is the medical approach, while one phytonutrient can affect 1000 genes/or pathways, or more. Add the synergistic benefit of say 400 bioactive nutrients in ginger and you could have up and down regulation of all sorts of functions - also in the data Tables.
Great study: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029837