"...It describes how ALC-0315 â one of the molecules used to create Comirnatyâs nanoparticle delivery system â forms âproinflammatory cytokines and ROS that can disrupt the mitochondrial membrane and release its content, cause RNA mistranslation, polymerization of proteins and DNA, DNA mutations, destruction of the nuclear membrane and consequent release of its content.â"
From: "New Safety Concerns About the COVID Shots Arise"
Dr Kevin McKernan has critiqued the new vaccine integration paper and he doesn't dismiss the paper as fraudulent, but does ask for more confirmations, which isn't surprising at all:
Kevin McKernan
@Kevin_McKernan
As much as I suspect people will eventually find integration, this paper needs a few more confirmations.
1)Same primers were used for nested PCR for 70 cycles.
2)the alignments are noisy.
3)follow up whole genome sequencing or Tag-seq is required to get the flanking genomic seq.
Great job as usual @doorlesscarp! It'll take me a week to digest this. A few questions / pointers:
1) Taurine is able to (if not reduce, at least) regulate the cardiomyopathy risk associated with elevated/dysregulated mPTP Ca2+ accumulation. It may not reverse the mPTP dysregulation, but adequate levels seem to regulate the ensuing ROS damage somewhat (at least in mouse cardiomyocyte models).
Would any of the above be worth investigating further in your opinion?
Very preliminary: based on the above, mitigating (and as per literature, probably safe) dosage recommendations would be c.
1) Taurine 3-5 g/daily
2) Cyclosporin A not widely/easily available and due to immunosuppressing/interleuking modulating effects, not easy to recommend/dose.
3) Metformin treatment response from patients being treated for PASC glucose dysregulation seem to be favourable, but not sure of whether CA2+ mPTP related or due to other pathways. Better to consult your prescribing doc.
Thank you Satyanvesh. Some great suggestions there that would probably justify a Substack on their own for each. I've hesitated about Metformin or It's homologues before as it can drop your blood sugar and diabetes is more likely to be prevalent in the groups with mitochondrial dysfunction and looking for alternatives.
Thank you for your excellent work. I haven't had a chance to read it all.
I am viewing what happened as war crimes, no guns were used but the weapons are in some ways worse. They even call them shots.
They made us do it to each other and ourselves.
Had we taken people out in the street and used a gun there would be uproar - seems we accept killing quite readily as long as there is no blood or gore involved.
A certain lab mouse found this patent by Biontech in 2016. Amazing how they did all this work, 4 years before.
The "invention" also considers use of a promoter, possibly as used in Plasmid DNA.
***
3' utr sequences for stabilization of rna
"...The term "nucleic acid sequence of the 3 ' -untranslated region of MT_R R1, a fragment thereof, or a variant of said nucleic acid sequence or fragment" relates to a nucleic acid sequence comprising, preferably consisting of a nucleic acid sequence selected from the group consisting of SEQ ID NOs : 105 to 121 of the sequence listing or a fragment thereof..."
I didn't realize that nanotubes could operate outside the cell. The Harry Potter image, however, made it all come clear.
"The researchers found that nanotube inhibitors prevented hijacking and restored the action of checkpoint inhibitors. At first it may sound like an effective treatment, but nanotubes facilitate so many essential trafficking functions that total inhibition would quickly lead to all manner of disorders."
Yeah, right. No surprise there! Another approach would be to research the underlying (root) causes of all this biochemical chaos, and stop doing whatever it is that produces it. I only wish it were that simple. Our modern way of life, unfortunately, resides on top of layer upon layer of science-enabled industrial poisoning. Is this a mistake, or a carefully planned death trap? Some of both? I don't know. What would Harry say?
I'm only a layman in these matters, albeit well read.
As regards gene therapies what strikes me is that when/if "faulty" genes leading to illness are corrected, then doesn't the immune system inevitably try to destroy said correct genes because they are inevitably recognised as being foreign and dangerous?
So, âAlthough S1 improved mitochondrial function in AC16 cells in the short term, prolonged S1 treatment led to mitochondrial dysfunction due to the disruption of ÎĎm, mitochondrial Ca2+ overload, accumulation of ROS, and alteration of mitochondrial dynamics. These effects of subunit S1 of the S protein translate into irreversible cardiac remodeling.â But yes, sure, letâs jab millions and hey, letâs promote those boosters! IRREVERSIBLE cardiac remodeling, ah, sounds good.
Wow, wow, wow! Dynamite job putting this together. Sadly, it is more than an evening reading. Iâm afraid it will take me a couple of sit downs. Iâm sure Iâll have questions.
âA more economical way would be to limit mitochondrial damage in the first place by taking antioxidants, many of which also promote recovery of mitochondria too.
These include baicalin, turmeric, CBD, quercetin, berberine, vitamin D, NAC,31 resveratrol, and epigallocatechin-3-gallate.â Thanks DC!
mRNA Covid Vaccines Worsen Diabetes, Study Finds
Sadly, Covid does the same thing
IGOR CHUDOV
6 JAN 2024
https://www.igor-chudov.com/p/mrna-covid-vaccines-worsen-diabetes
Hat tip to Dr Mercola for linking to these two papers from 2023 that discuss how LNP components also damage mitochondria.
Of course the "regulators" are nowhere:
Chemical-physical criticality and toxicological potential of lipid nanomaterials contained in a COVID-19 mRNA vaccine
https://ijvtpr.com/index.php/IJVTPR/article/view/68
Apparent Cytotoxicity and Intrinsic Cytotoxicity of Lipid Nanomaterials Contained in a COVID-19 mRNA Vaccine
https://www.researchgate.net/publication/374760573_Apparent_Cytotoxicity_and_Intrinsic_Cytotoxicity_of_Lipid_Nanomaterials_Contained_in_a_COVID-19_mRNA_Vaccine
"...It describes how ALC-0315 â one of the molecules used to create Comirnatyâs nanoparticle delivery system â forms âproinflammatory cytokines and ROS that can disrupt the mitochondrial membrane and release its content, cause RNA mistranslation, polymerization of proteins and DNA, DNA mutations, destruction of the nuclear membrane and consequent release of its content.â"
From: "New Safety Concerns About the COVID Shots Arise"
https://articles.mercola.com/sites/articles/archive/2024/01/02/rna-instability.aspx
Updated with a new section:
26th December â23: (Melatonin: a potent protector of mitochondria).
https://doorlesscarp953.substack.com/p/sars-cov-2-spike-protein-mitochondrial
Dr Kevin McKernan has critiqued the new vaccine integration paper and he doesn't dismiss the paper as fraudulent, but does ask for more confirmations, which isn't surprising at all:
Kevin McKernan
@Kevin_McKernan
As much as I suspect people will eventually find integration, this paper needs a few more confirmations.
1)Same primers were used for nested PCR for 70 cycles.
2)the alignments are noisy.
3)follow up whole genome sequencing or Tag-seq is required to get the flanking genomic seq.
https://x.com/Kevin_McKernan/status/1738083826449236255?s=20
Great job as usual @doorlesscarp! It'll take me a week to digest this. A few questions / pointers:
1) Taurine is able to (if not reduce, at least) regulate the cardiomyopathy risk associated with elevated/dysregulated mPTP Ca2+ accumulation. It may not reverse the mPTP dysregulation, but adequate levels seem to regulate the ensuing ROS damage somewhat (at least in mouse cardiomyocyte models).
https://pubmed.ncbi.nlm.nih.gov/36963206/
&
https://pubmed.ncbi.nlm.nih.gov/11787652/
2) Cyclosporin A seems to rapidly reverse mPTP permeability changes (under specific conditions, see paper). https://pubmed.ncbi.nlm.nih.gov/11787652/
3) Metformin seems also to stabilize Ca2+ homeostasis, although the details still escape me. Perhaps useful in this regard, need more study?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430509/
Would any of the above be worth investigating further in your opinion?
Very preliminary: based on the above, mitigating (and as per literature, probably safe) dosage recommendations would be c.
1) Taurine 3-5 g/daily
2) Cyclosporin A not widely/easily available and due to immunosuppressing/interleuking modulating effects, not easy to recommend/dose.
3) Metformin treatment response from patients being treated for PASC glucose dysregulation seem to be favourable, but not sure of whether CA2+ mPTP related or due to other pathways. Better to consult your prescribing doc.
Thank you Satyanvesh. Some great suggestions there that would probably justify a Substack on their own for each. I've hesitated about Metformin or It's homologues before as it can drop your blood sugar and diabetes is more likely to be prevalent in the groups with mitochondrial dysfunction and looking for alternatives.
Thank you for your excellent work. I haven't had a chance to read it all.
I am viewing what happened as war crimes, no guns were used but the weapons are in some ways worse. They even call them shots.
They made us do it to each other and ourselves.
Had we taken people out in the street and used a gun there would be uproar - seems we accept killing quite readily as long as there is no blood or gore involved.
"The death of one man is a tragedy, the death of millions is a statistic."
https://reason.com/2009/01/07/the-death-of-one-man-is-a-trag/
A certain lab mouse found this patent by Biontech in 2016. Amazing how they did all this work, 4 years before.
The "invention" also considers use of a promoter, possibly as used in Plasmid DNA.
***
3' utr sequences for stabilization of rna
"...The term "nucleic acid sequence of the 3 ' -untranslated region of MT_R R1, a fragment thereof, or a variant of said nucleic acid sequence or fragment" relates to a nucleic acid sequence comprising, preferably consisting of a nucleic acid sequence selected from the group consisting of SEQ ID NOs : 105 to 121 of the sequence listing or a fragment thereof..."
https://patents.google.com/patent/WO2017060314A2/en
I didn't realize that nanotubes could operate outside the cell. The Harry Potter image, however, made it all come clear.
"The researchers found that nanotube inhibitors prevented hijacking and restored the action of checkpoint inhibitors. At first it may sound like an effective treatment, but nanotubes facilitate so many essential trafficking functions that total inhibition would quickly lead to all manner of disorders."
Yeah, right. No surprise there! Another approach would be to research the underlying (root) causes of all this biochemical chaos, and stop doing whatever it is that produces it. I only wish it were that simple. Our modern way of life, unfortunately, resides on top of layer upon layer of science-enabled industrial poisoning. Is this a mistake, or a carefully planned death trap? Some of both? I don't know. What would Harry say?
Walter just linked to this, which I missed as it was also published 23rd December.
The title tells you the story.
If anything it understates the risk as it doesn't consider persistence of biosynthetic Spike:
Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model
https://www.cell.com/iscience/fulltext/S2589-0042(23)02718-9?utm_source=substack&utm_medium=email
I'm only a layman in these matters, albeit well read.
As regards gene therapies what strikes me is that when/if "faulty" genes leading to illness are corrected, then doesn't the immune system inevitably try to destroy said correct genes because they are inevitably recognised as being foreign and dangerous?
Get round that at someone else's peril.
Doorless Cyprinus Carpio - Not very good, but excellent sleuthing. Never let a STAT-3 inhibitor get between a copper top and their "insulin".
See mcgdoc.substack.com for the new technology developed by Dr. Joseph Shen to replace the EKG and reveal hidden damage to the heart.
Thanks for the linkđ
MOTS-c depletion a contributory factor:
Patient Presentations in a Community Pain Clinic after COVID-19 Infection or Vaccination: A Case-Series Approach
https://www.mdpi.com/2039-7283/13/6/139
So, âAlthough S1 improved mitochondrial function in AC16 cells in the short term, prolonged S1 treatment led to mitochondrial dysfunction due to the disruption of ÎĎm, mitochondrial Ca2+ overload, accumulation of ROS, and alteration of mitochondrial dynamics. These effects of subunit S1 of the S protein translate into irreversible cardiac remodeling.â But yes, sure, letâs jab millions and hey, letâs promote those boosters! IRREVERSIBLE cardiac remodeling, ah, sounds good.
Wow, wow, wow! Dynamite job putting this together. Sadly, it is more than an evening reading. Iâm afraid it will take me a couple of sit downs. Iâm sure Iâll have questions.
âA more economical way would be to limit mitochondrial damage in the first place by taking antioxidants, many of which also promote recovery of mitochondria too.
These include baicalin, turmeric, CBD, quercetin, berberine, vitamin D, NAC,31 resveratrol, and epigallocatechin-3-gallate.â Thanks DC!