I'm one of those people that has an allele found in about 5% of people of European extract. It is called CYP3A4*22 - a genetic SNP that causes reduced generation of this liver enzyme. Therefore, it is necessary to carefully evaluate supplements that are substrates or inhibitors of CYP3A4, as this particular enzyme is used to metabolize about 50% of all pharmaceuticals, as well as some common foods and supplements as listed in the paragraph above,
"While the beneficial effects of the commonly consumed herbal products by cancer patients is uncertain, data from human studies suggest that some of these supplements are capable of interacting with chemotherapeutic agents. It is therefore prudent and advisable to avoid the concomitant use of anti-cancer drugs and herbal products, especially echinacea, garlic, ginseng, grapefruit juice, milk thistle, and St John's wort."
A reduced version of this enzyme effectively increases the AUC of the medicines/metabolites that are processed by CYP3A4 - not only chemotherapeutics. I believe that is why some people have adverse effects from common meds taken at recommended dosages. I am one of these people, and I must take 1/2 dose of various medicines in order to avoid nasty side effects. If a reader has a long history of using the children's dose because it works fine and avoids headaches and such, he might have this allele.
Interesting then to compare to experience of Stephen Harrod, herbalist. He insist on using only angustifolia. And only in the beginning, because echinacea works only on the surface of cells. Because pure angustifolia i could not find, i used mixed and it works very well in the beginning of painfull throat.
The key to is you have to start taking it immediately at the sign of first symptoms. Frequency and quantity are the biggest reasons people think herbs don't work. Potency/quality also matters, but don't overthink it. Thanks for the reminder, I have a lot of herbs on hand, but am out of this one. (Herbs you run out of are a good sign that they get used first! Lol)
I've used echinacea for years. I used it for one really bad strain of flu that was going around and was able to keep working while the rest of them were suffering badly. I think the trick is to take a lot of it. Farmers used to feed it to their horses. I took a lot of it in the winter, and it was like I could feel the heat from it.
I'm one of those people that has an allele found in about 5% of people of European extract. It is called CYP3A4*22 - a genetic SNP that causes reduced generation of this liver enzyme. Therefore, it is necessary to carefully evaluate supplements that are substrates or inhibitors of CYP3A4, as this particular enzyme is used to metabolize about 50% of all pharmaceuticals, as well as some common foods and supplements as listed in the paragraph above,
"While the beneficial effects of the commonly consumed herbal products by cancer patients is uncertain, data from human studies suggest that some of these supplements are capable of interacting with chemotherapeutic agents. It is therefore prudent and advisable to avoid the concomitant use of anti-cancer drugs and herbal products, especially echinacea, garlic, ginseng, grapefruit juice, milk thistle, and St John's wort."
A reduced version of this enzyme effectively increases the AUC of the medicines/metabolites that are processed by CYP3A4 - not only chemotherapeutics. I believe that is why some people have adverse effects from common meds taken at recommended dosages. I am one of these people, and I must take 1/2 dose of various medicines in order to avoid nasty side effects. If a reader has a long history of using the children's dose because it works fine and avoids headaches and such, he might have this allele.
Interesting then to compare to experience of Stephen Harrod, herbalist. He insist on using only angustifolia. And only in the beginning, because echinacea works only on the surface of cells. Because pure angustifolia i could not find, i used mixed and it works very well in the beginning of painfull throat.
I ordered some today. Thank you. ❤️👍
The key to is you have to start taking it immediately at the sign of first symptoms. Frequency and quantity are the biggest reasons people think herbs don't work. Potency/quality also matters, but don't overthink it. Thanks for the reminder, I have a lot of herbs on hand, but am out of this one. (Herbs you run out of are a good sign that they get used first! Lol)
I've used echinacea for years. I used it for one really bad strain of flu that was going around and was able to keep working while the rest of them were suffering badly. I think the trick is to take a lot of it. Farmers used to feed it to their horses. I took a lot of it in the winter, and it was like I could feel the heat from it.
Thank you for this! Echinacea had kind of dropped off my radar