This post looks at HIV-1 Tat arginine sequences that seem to appear in Spike, and pertains both to destruction of immune cells and to mitochondrial dysfunction.
Excellent Substack, thanks. I also considered gp120 binding with neurofilaments, it doesn't necessarily kill the neuron but it can inhibit transmission ie a feature of LC.
And a terrifying hypothesis I didn't originate but contributed to is that transfection derived exosomes like those with HIV-TAT can demethylate ACE2 promotors, triggering expression in almost any cell type and therefore facilitate extreme systemic ADE.
đŻ
Epstein-Barr Virus Lytic Replication Induces ACE2 Expression and Enhances SARS-CoV-2 Pseudotyped Virus Entry in Epithelial Cells
But of course -- ACE2 as a metalloprotease. That's what my next entry will deal with. Various MMPs upregulated by the arginine-rich-sequence of Tat, and apparently also Spike.
MMP disbalance ---> lung interface destroyed / BBB damage; gobs of clots in autopsy...
Another great post, thank you. I added some of this info to my post and mentioned yours:
https://medquotes.substack.com/p/not-new-arginine-hiv-tat-lab-tool
This post looks at HIV-1 Tat arginine sequences that seem to appear in Spike, and pertains both to destruction of immune cells and to mitochondrial dysfunction.
Excellent Substack, thanks. I also considered gp120 binding with neurofilaments, it doesn't necessarily kill the neuron but it can inhibit transmission ie a feature of LC.
And a terrifying hypothesis I didn't originate but contributed to is that transfection derived exosomes like those with HIV-TAT can demethylate ACE2 promotors, triggering expression in almost any cell type and therefore facilitate extreme systemic ADE.
đŻ
Epstein-Barr Virus Lytic Replication Induces ACE2 Expression and Enhances SARS-CoV-2 Pseudotyped Virus Entry in Epithelial Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316011/
Woah, that's wild.
But of course -- ACE2 as a metalloprotease. That's what my next entry will deal with. Various MMPs upregulated by the arginine-rich-sequence of Tat, and apparently also Spike.
MMP disbalance ---> lung interface destroyed / BBB damage; gobs of clots in autopsy...