For bone mets, breast cancer patients have long been advised to take doxy.
My wariness with doxy as being a member of the tetracycline family is: "Tetracyclines, Even at low concentrations, tetracyclines induce mitochondrial proteotoxic stress, leading to changes in nuclear gene expression and altered mitochondrial dynamics and function in commonly used cell types, as well as worms, flies, mice, and plants. "
Mitochondria, of course, are comprised of vestigial bacteria. Are we destroying our mitochondria by doxy's attack on mitochondria? I am passionate about helping cancer patients, especially breast cancer patients, and I have always passed along this caveat.
Thanks Sally, another one of the reasons to caution against taking it long term or as a prophylactic. If you are late stage metastatic and all other treatments are being resisted it's the least worse option. But as with other drugs including IVM we advise reducing doseage as soon as you are able to. Iron overdose is another risk!
The case which prompted this review was already being prescribed doxycycline for something else, were there any interactions to be aware of? Fortunately not but researching it did uncover the "off target" effects.
The key point I try to make to doctors is that it isnāt rocket science but it does need good understanding of the chemistry, manufacturing and controls rules- the supply chain make the stuff that goes in the body :)
I also just cracked the pandora's box of searching Doxycycline + Transferrin, to see if the ligand motif itself might have a direct interaction..... that rabbit hole must wait a few weeks.
As always, thank you, Doorless Carp!
For bone mets, breast cancer patients have long been advised to take doxy.
My wariness with doxy as being a member of the tetracycline family is: "Tetracyclines, Even at low concentrations, tetracyclines induce mitochondrial proteotoxic stress, leading to changes in nuclear gene expression and altered mitochondrial dynamics and function in commonly used cell types, as well as worms, flies, mice, and plants. "
Mitochondria, of course, are comprised of vestigial bacteria. Are we destroying our mitochondria by doxy's attack on mitochondria? I am passionate about helping cancer patients, especially breast cancer patients, and I have always passed along this caveat.
THANKS AGAIN, DOORLESS CARP!
Thanks Sally, another one of the reasons to caution against taking it long term or as a prophylactic. If you are late stage metastatic and all other treatments are being resisted it's the least worse option. But as with other drugs including IVM we advise reducing doseage as soon as you are able to. Iron overdose is another risk!
Thanks for this Mr Carp! Readers may find this if interested, written when I was helping Dr Tess Lawrie on IVM approval by MHRA: https://www.dropbox.com/s/4ygwnz4o76exd5i/GMP%20Vol20No2_Rees.pdf?dl=0
Thanks Hedley, that's really useful advice.
The case which prompted this review was already being prescribed doxycycline for something else, were there any interactions to be aware of? Fortunately not but researching it did uncover the "off target" effects.
The key point I try to make to doctors is that it isnāt rocket science but it does need good understanding of the chemistry, manufacturing and controls rules- the supply chain make the stuff that goes in the body :)
Good thing about doxy is that, similar to IVM, it's not a complex biological and has a long regulatory history.
Exciting article, thank you.
So is there a connection between the possible benefit of iron chelation via Doxycycline
with Spike's use of Transferrin Receptor...
This is quite an old paper. There would be an effect, but it depends...
Effect of iron chelators on the transferrin receptor in K562 cells
K R Bridges et al. J Biol Chem. 1984.
https://pubmed.ncbi.nlm.nih.gov/6092356/
I also just cracked the pandora's box of searching Doxycycline + Transferrin, to see if the ligand motif itself might have a direct interaction..... that rabbit hole must wait a few weeks.
C19 showed that the flu could be treated with the same meds - per the late Dr Zelenko.
Of course, it also showcased the wondrous ivermectin, which has many uses.
Hi Spiro, thanks, and that's a great tip. We need all the cytokine Inhibiting therapies we can get, noted.