Any extracts used in the following article are for non commercial research and educational purposes only and may be subject to copyright from their respective owners. Background & Definitions The kynurenine pathway is a metabolic pathway leading to the production of nicotinamide adenine dinucleotide (NAD+). Metabolites involved in the kynurenine pathway include tryptophan, kynurenine, kynurenic acid, xanthurenic acid, quinolinic acid, and 3-hydroxykynurenine. The kynurenine pathway is responsible for total catabolization of tryptophan about 95%. Disruption in the pathway is associated with certain genetic and psychiatric disorders.
DoorlessCarp, would you consider making this into a pdf download? This is REALLY GOOD and I think a pdf with your authorship - heck put a watermark in it too! - this would be GREAT presentation and I think it would be a great CME too.
Jul 29, 2022·edited Jul 29, 2022Liked by DoorlessCarp🐭
Woooow!!!! Amaaaaaazing work!!!! Feel like I have just witnessed a BIG BANG Explosion of knowledge.
DoorlessCarp since you mentioned Astaxanthin and a lot of similar vitamins to what Patrick Theut recommends as part of his "Reverse CAC score & Heart Disease" I am sharing the link (pls see below) for Longecity.org forum on how to reverse arterial plaque and also an Abstract from Patrick Theut's interview with Ivor Cummins, your perusal.
Feel Free to delete my post if there is anything you feel uncomfortable about it. The only reason I am sharing it is because I think it might be of value to you and your readers. And it is a great protocol as well as Interview. The whole approach to reversing arterial plaque is awesome and I have not heard the better one anywhere.
HDL & LDL will kill & clean out macrophage foam cells with high serum levels of the following:
• LDL
• HDL
• Free T3 between 3.3 & 5.0 pg/ml
• K1, MK-4, & MK-7 koncentrated k supplies all these
• CoQ10
• Vit D3 vit-D, 25-OH between 60 &70
• Vit E
• Vit C Patrick takes 6 g/d, but realizes that is too high for most people
• Magnesium
• Selenium optimum is 200 ug/day (total including food)
• Omega 3's with fat [I take DHA & EPA extracts and avoid fish oil]
• Do not take Calcium or Arginine
• Take Lysine & Citrulline
Abstract from Patrick Theut's interview with Ivor Cummins plus [Editorial comments]
• Heart disease reversal/prevention requires high serum levels of vitamin K1 and vitamin MK-7 .
• Vitamin K: There is one K1 and 13 [misspoken] K2's. [Edit: The K2's are MK-4 thru MK-13, where the number indicates the length of a molecule chain. So there are 10 of them.]
• K1 is made by plants. It's high in broccoli & Kale.
• K2's come from fermented food products or fermentation by gut bacteria. Carbs feed the wrong type of gut bacteria. Carbs can kill K2 production in your gut. A low carb ketogenic diet is essential for the gut to make K2s. [Edit: Its best to supplement K2's instead of worrying about gut bacteria making them.]
Need for K1, vit-C, and "large fluffy" LDL
• Macrophages inside your cell wall turn into foam cells that cause constant inflammation and the build up of plaque.
• Initially, monocytes patrolling the inside of arteries pull damaged (gluconated or oxidized) lipids and bacteria out of the blood, then become macrophages inside the cell wall.
• Once macrophages job is done they need to be killed, else they become "foam cells", bloated with droplets of cholesterol.
• LDL carries K1 & vit-C. If it has enough K1 and Vit-C it will kill the macrophages that eat it. If there is not enough of either K1 or Vit-C, the macrophages will gorge on LDL and become foam cells.
• This explains why a vegetarian diet high enough in K1 and vit-C could prevent athersclerosis.
• Small LDL cannot carry enough K1, so small LDL will always feed foam cells. You need large fluffy LDL and enough K1 & Vit-C in order to stay healthy.
Need for vit-D & free-T3
• You've got macrophages and foam cells growing and you've got to kill them.
• If you have enough vit-D and enough free T3 (thyroid hormone), there will be proteins on the surface of macrophages that start spinning. This attracts HDL.
Need for MK-7, CoQ10, Micro-RNA, and "large fluffy" HDL
• MK-7 on the HDL locks onto the spinning protein on macrophages or foam cells and locks it down.
• The COQ10 on HDL then binds tightly to the macrophage. Then Micro-RNA from the HDL enters the macrophage (or foam cell) and kills it.
• The HDL then sucks out the fat & cholesterol and when its all bloated it returns to the liver.
• Small HDL cannot carry enough MK7, CoQ10, & Micro-RNA, so it cannot kill foam cells.
• The difference in surface area between small & large HDL is 900%.
• In addition, small HDL cannot orient MK7 & CoQ10 properly to lock onto a macrophage.
Need for magnesium
• A little-known carrier protein is attracted into the artery wall by spinning proteins on macrophages.
• If there is enough magnesium to loosen calcium from muscle cells in the arterial wall, this carrier protein can grab onto the calcium and remove it.
Diet
• Inadequate diet will make LDL & HDL too small
• Will not provide enough K1, vit-C, vit-D, free-T3, MK7, CoQ10, and magnesium.
• High dietary levels create more K1 & vit-C on in LDL
• High dietary levels create a better coating of MK-7, CoQ-10, and Micro-RNA on HDL
• High dietary levels of vit-D and free-T3 create the spinning molecules on macrophages
HDL & LDL will kill & clean out macrophage foam cells with high serum levels of the following:
• LDL
• HDL
• Free T3 between 3.3 & 5.0 pg/ml
• K1, MK-4, & MK-7 koncentrated k supplies all these
• CoQ10
• Vit D3 vit-D, 25-OH between 60 &70
• Vit E
• Vit C Patrick takes 6 g/d, but realizes that is too high for most people
• Magnesium
• Selenium optimum is 200 ug/day (total including food)
• Omega 3's with fat [I take DHA & EPA extracts and avoid fish oil]
• Do not take Calcium or Arginine
• Take Lysine & Citrulline
• One thing to add, since not many would take the time to watch long videos, is that Patrick since almost 2 decades has sieved anything he could find in the available scientific literature (his product page is a testimony to that in respect to K-vitamins only), and is propably the only individual who lab-tested himself the most.
•
• For example, by repeatedly testing undercarboxylated osteocalcin as a proxi for vitamin K2, he found that no high doses of K2 vitamins can be too much, to bring it down to healthier levels. So he know's his own metabolism very well. And many of his recommentations originate from that.
•
• Doing a lot of lab-testing myself (not even nearly as much), I want to point out that there are immense differences in bio-chemical individuality. For example my selenium only came in the optimal range with 370 mcg/d of selenium (incl. food).
• He thinks a carrot a day gives enough preforemed vitamin A. And the liver know's by itself how much is actually needed. In his later video he admits that there are of course genetic differences. I also found carrots not enough, but the need for high doses of preformed vitamin A to raise serum levels to optimal.
• My biome showed I've complete lack in vitamin K1 to K2 metabolizing bacteria, despite being low carb since a decade.
• Only Mg-sulfate IVs, beside supplementing up to 2.5 g of oral elemental Mg a day, finally started to improve my severe Mg-deficiency.
• My rhinitis eats up so much vitamin C for its antihistamine properties, I actually supplemented 24 g/d, and would still do better with more of that stuff.
• So take what it takes, acertained with frequent lab-testing.
•
• Despite obviously being deficient in freeT3 and Mg, I too could halt the mercyless growth in calcification. We are all deferent.
started taking C60oo in early August, 2012, and it has reduced the depth of the wrinkles on my face, as seen in the photos on my profile.
I also noticed fading of two deep scars after Turnbuckle noted that he saw scars fading, likely due to C60oo's potent antioxidant effect improving the health of skin's elastin and collagen.
I assume that the external anti-aging improvements that I've experienced are accompanied by internal improvements.
However, while C60oo appears to reduce the potential for Alzheimer's, cancers, liver inflammation and other potential problems that would limit lifespan, it does not appear to affect cardiovascular issues - blood lipids, etc...
So, with finding out that I have some plaque, I began researching the potential to reverse arterial plaque and improve overall cardiovascular function with a goal of living far past 100 years of age in good health.
I then found a study that showed that high-dose vitamin K2 (MK4) reversed arterial plaque in rats ~37% in just six weeks.
DoorlessCarp, would you consider making this into a pdf download? This is REALLY GOOD and I think a pdf with your authorship - heck put a watermark in it too! - this would be GREAT presentation and I think it would be a great CME too.
THANK YOU!
This is going to be a 3-day study to get as much as I can into long-term memory. I am passing it along!
Wow.
Woooow!!!! Amaaaaaazing work!!!! Feel like I have just witnessed a BIG BANG Explosion of knowledge.
DoorlessCarp since you mentioned Astaxanthin and a lot of similar vitamins to what Patrick Theut recommends as part of his "Reverse CAC score & Heart Disease" I am sharing the link (pls see below) for Longecity.org forum on how to reverse arterial plaque and also an Abstract from Patrick Theut's interview with Ivor Cummins, your perusal.
Feel Free to delete my post if there is anything you feel uncomfortable about it. The only reason I am sharing it is because I think it might be of value to you and your readers. And it is a great protocol as well as Interview. The whole approach to reversing arterial plaque is awesome and I have not heard the better one anywhere.
https://www.longecity.org/forum/topic/65884-reversing-arterial-plaque/page-1
https://www.longecity.org/forum/topic/111100-patrick-theut-reverse-cac-score-heart-disease/?ref=tfrecipes
Patrick Theut "Reverse CAC score & Heart Disease"
HDL & LDL will kill & clean out macrophage foam cells with high serum levels of the following:
• LDL
• HDL
• Free T3 between 3.3 & 5.0 pg/ml
• K1, MK-4, & MK-7 koncentrated k supplies all these
• CoQ10
• Vit D3 vit-D, 25-OH between 60 &70
• Vit E
• Vit C Patrick takes 6 g/d, but realizes that is too high for most people
• Magnesium
• Selenium optimum is 200 ug/day (total including food)
• Omega 3's with fat [I take DHA & EPA extracts and avoid fish oil]
• Do not take Calcium or Arginine
• Take Lysine & Citrulline
Abstract from Patrick Theut's interview with Ivor Cummins plus [Editorial comments]
• Heart disease reversal/prevention requires high serum levels of vitamin K1 and vitamin MK-7 .
• Vitamin K: There is one K1 and 13 [misspoken] K2's. [Edit: The K2's are MK-4 thru MK-13, where the number indicates the length of a molecule chain. So there are 10 of them.]
• K1 is made by plants. It's high in broccoli & Kale.
• K2's come from fermented food products or fermentation by gut bacteria. Carbs feed the wrong type of gut bacteria. Carbs can kill K2 production in your gut. A low carb ketogenic diet is essential for the gut to make K2s. [Edit: Its best to supplement K2's instead of worrying about gut bacteria making them.]
Need for K1, vit-C, and "large fluffy" LDL
• Macrophages inside your cell wall turn into foam cells that cause constant inflammation and the build up of plaque.
• Initially, monocytes patrolling the inside of arteries pull damaged (gluconated or oxidized) lipids and bacteria out of the blood, then become macrophages inside the cell wall.
• Once macrophages job is done they need to be killed, else they become "foam cells", bloated with droplets of cholesterol.
• LDL carries K1 & vit-C. If it has enough K1 and Vit-C it will kill the macrophages that eat it. If there is not enough of either K1 or Vit-C, the macrophages will gorge on LDL and become foam cells.
• This explains why a vegetarian diet high enough in K1 and vit-C could prevent athersclerosis.
• Small LDL cannot carry enough K1, so small LDL will always feed foam cells. You need large fluffy LDL and enough K1 & Vit-C in order to stay healthy.
Need for vit-D & free-T3
• You've got macrophages and foam cells growing and you've got to kill them.
• If you have enough vit-D and enough free T3 (thyroid hormone), there will be proteins on the surface of macrophages that start spinning. This attracts HDL.
Need for MK-7, CoQ10, Micro-RNA, and "large fluffy" HDL
• MK-7 on the HDL locks onto the spinning protein on macrophages or foam cells and locks it down.
• The COQ10 on HDL then binds tightly to the macrophage. Then Micro-RNA from the HDL enters the macrophage (or foam cell) and kills it.
• The HDL then sucks out the fat & cholesterol and when its all bloated it returns to the liver.
• Small HDL cannot carry enough MK7, CoQ10, & Micro-RNA, so it cannot kill foam cells.
• The difference in surface area between small & large HDL is 900%.
• In addition, small HDL cannot orient MK7 & CoQ10 properly to lock onto a macrophage.
Need for magnesium
• A little-known carrier protein is attracted into the artery wall by spinning proteins on macrophages.
• If there is enough magnesium to loosen calcium from muscle cells in the arterial wall, this carrier protein can grab onto the calcium and remove it.
Diet
• Inadequate diet will make LDL & HDL too small
• Will not provide enough K1, vit-C, vit-D, free-T3, MK7, CoQ10, and magnesium.
• High dietary levels create more K1 & vit-C on in LDL
• High dietary levels create a better coating of MK-7, CoQ-10, and Micro-RNA on HDL
• High dietary levels of vit-D and free-T3 create the spinning molecules on macrophages
HDL & LDL will kill & clean out macrophage foam cells with high serum levels of the following:
• LDL
• HDL
• Free T3 between 3.3 & 5.0 pg/ml
• K1, MK-4, & MK-7 koncentrated k supplies all these
• CoQ10
• Vit D3 vit-D, 25-OH between 60 &70
• Vit E
• Vit C Patrick takes 6 g/d, but realizes that is too high for most people
• Magnesium
• Selenium optimum is 200 ug/day (total including food)
• Omega 3's with fat [I take DHA & EPA extracts and avoid fish oil]
• Do not take Calcium or Arginine
• Take Lysine & Citrulline
• One thing to add, since not many would take the time to watch long videos, is that Patrick since almost 2 decades has sieved anything he could find in the available scientific literature (his product page is a testimony to that in respect to K-vitamins only), and is propably the only individual who lab-tested himself the most.
•
• For example, by repeatedly testing undercarboxylated osteocalcin as a proxi for vitamin K2, he found that no high doses of K2 vitamins can be too much, to bring it down to healthier levels. So he know's his own metabolism very well. And many of his recommentations originate from that.
•
• Doing a lot of lab-testing myself (not even nearly as much), I want to point out that there are immense differences in bio-chemical individuality. For example my selenium only came in the optimal range with 370 mcg/d of selenium (incl. food).
• He thinks a carrot a day gives enough preforemed vitamin A. And the liver know's by itself how much is actually needed. In his later video he admits that there are of course genetic differences. I also found carrots not enough, but the need for high doses of preformed vitamin A to raise serum levels to optimal.
• My biome showed I've complete lack in vitamin K1 to K2 metabolizing bacteria, despite being low carb since a decade.
• Only Mg-sulfate IVs, beside supplementing up to 2.5 g of oral elemental Mg a day, finally started to improve my severe Mg-deficiency.
• My rhinitis eats up so much vitamin C for its antihistamine properties, I actually supplemented 24 g/d, and would still do better with more of that stuff.
• So take what it takes, acertained with frequent lab-testing.
•
• Despite obviously being deficient in freeT3 and Mg, I too could halt the mercyless growth in calcification. We are all deferent.
started taking C60oo in early August, 2012, and it has reduced the depth of the wrinkles on my face, as seen in the photos on my profile.
I also noticed fading of two deep scars after Turnbuckle noted that he saw scars fading, likely due to C60oo's potent antioxidant effect improving the health of skin's elastin and collagen.
I assume that the external anti-aging improvements that I've experienced are accompanied by internal improvements.
However, while C60oo appears to reduce the potential for Alzheimer's, cancers, liver inflammation and other potential problems that would limit lifespan, it does not appear to affect cardiovascular issues - blood lipids, etc...
So, with finding out that I have some plaque, I began researching the potential to reverse arterial plaque and improve overall cardiovascular function with a goal of living far past 100 years of age in good health.
I then found a study that showed that high-dose vitamin K2 (MK4) reversed arterial plaque in rats ~37% in just six weeks.
Please see: http://bloodjournal....109/7/2823.long
So, I began taking 5 mg three times a day. I'm raising it to 15 mg, tid, because it is not toxic and I've seen multiple recommendations for 45 mg/day.
I'm also taking vitamin K2 (MK7) 400 mcg/day. It's half life is three days, so I only need to take it once a day.
K1 has beneficial effects for bone, but not plaque, but I am taking 200 mcg/day of it, also.
Turnbuckle enlightened me about xanthohumol's beneficial effects on arterial plaque and HDL, so I'm adding that to my supplement regimen.
Please see: http://www.ncbi.nlm....les/PMC3500296/
I invite you to join in on this pursuit of a healthy, plaque-free cardiovascular system and welcome any insights that you might have.
• like x 4
IP6 (Inositol Hexaphosphate) to the rescue: http://ibdigital.uib...201.dir/201.pdf
"Phytate Inhibits Cardiovascular Calcifications"
---------------------------------------
You might also "Get Thee to a Blood Bank": http://www.healtheir...science-library
Iron status is associated with carotid atherosclerotic plaques in middle-aged adults
Body iron stores and presence of carotid atherosclerosis. Results from the Bruneck Study
Serum ferritin-a novel risk factor in acute myocardial infarction
Ferritin is independently associated with the presence of coronary artery calcium in 12,033 men
I like your K1&K2 dosages, keep it up. But make sure to consume sufficient fat when you take them.
Another great supplement for your purpose is pomegranate extract. LEF sells a very strong one.
Make sure you take sufficient magnesium as D3, K2, Vit A, Magnesium all work in synergy to keep calcium where it needs to be.
Will link this in my part two. Fucking great 👌🏻