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I'm helping a team collect data from public obituaries. Mindblowing. Babies, children, teens, young adults, adults (forget age 70+, even). Sudden passings, unexpected passings, in-the-night passings, sudden/aggressive cancers...
One of the articles above mentions: "cross-linked interstitial and perivascular matrix may be highly resistant to proteases. Matrix cross-linking enzymes, such as lysyl oxidases (13) and transglutaminase-2 (14), are markedly induced in remodeling and failing hearts, and may cause formation of irreversible fibrotic foci (Figure 1B)."
This is interesting in relation to Vojdani and Kharrazian (2020): "Looking at the reaction between SARS-CoV-2 spike protein antibody and tissue proteins (Fig. 1A), we found that the strongest reactions were with transglutaminase 3 (tTG3), transglutaminase 2 (tTG2), ENA, myelin basic protein (MBP), mitochondria, nuclear antigen (NA), α-myosin, thyroid peroxidase (TPO), collagen, claudin 5+6, and S100B."
Vojdani A, Kharrazian D. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Clin Immunol. 2020 Aug;217:108480. doi: 10.1016/j.clim.2020.108480.
So could that mean that there is a transglutaminase-2-similar motif in Spike, similar enough to trigger autoantibodies against the real transglutaminase 2, and similar enough to form irreversible cross-linking in the giant fibrous clots that are being found?
Honored to be the beneficiary of your efforts in sharing all of your scientific INFORMATION that I am trying my best to understand.
Bird, since your INFORMATION reflects your interest in HIV research, I am curious as to what you might think about this comment that I just read, that even the poster, investigative journalist, George Webb, conceded a need to be vetted:
"Wow, @dr_cottrell predicted five different binding sites for COVID in Feb 2020 including receptor CD-209. Guess what? The spike that binds to CD-209 also matches to CD-4, a key receptor in the downward path of HIV."
Hi Sally, thanks for pointing that out, I'd like to know more about that as well. I think Doorless Carp's answer would be a 40-page Review if we're lucky? I had an article started about CD-4/HIV but haven't gotten back to finish it. It seems that there are vulnerabilities to Spike being found in many if not all types of blood cells, white and red, including immature cells which are supposed to continually replenish our supply of fresh blood.
I'd like to see some data from hospitals on cell levels in all patients across the board, because from observation there are patients whose values are inexplicably waning. Combine those measurements with what we seem to be observing in acquaintances / in the news of common sicknesses hitting harder and longer. On the other hand, since these values are commonly tested in basic diagnostics, if there were a noticeable issue, it seems we would have heard more about it by now.
A topic with a lot of potential to look into. We'll have to all keep an eye on it.
Oh, yes, wonderful Doorless Carp would write a tome!
And the fact that there are receptors. in addition to the omnipresent ACE2 receptor, facilitating the entrance of the spike in all type of white and red blood cells, gives me pause. I fear for all of us - especially cancer patients.
I haven't followed that path through about coeliac yet, but it did cross my mind to wonder what implications that could have for diet: would the cross-reactivity Spike --> Transglutaminase Antibody eventually also have potential to be amplified Gluten --> Transglutaminase Antibody; if so that presents an interesting situation for world rice- vs. wheat-producing nations. (This wouldn't be the case if the Spike-triggered antibody is against a different part of Transglutaminase, which I'm not sure if we know yet?)
There's also the fertility issue with TG antibodies.
I'm helping a team collect data from public obituaries. Mindblowing. Babies, children, teens, young adults, adults (forget age 70+, even). Sudden passings, unexpected passings, in-the-night passings, sudden/aggressive cancers...
Interesting post as always, thank you.
One of the articles above mentions: "cross-linked interstitial and perivascular matrix may be highly resistant to proteases. Matrix cross-linking enzymes, such as lysyl oxidases (13) and transglutaminase-2 (14), are markedly induced in remodeling and failing hearts, and may cause formation of irreversible fibrotic foci (Figure 1B)."
This is interesting in relation to Vojdani and Kharrazian (2020): "Looking at the reaction between SARS-CoV-2 spike protein antibody and tissue proteins (Fig. 1A), we found that the strongest reactions were with transglutaminase 3 (tTG3), transglutaminase 2 (tTG2), ENA, myelin basic protein (MBP), mitochondria, nuclear antigen (NA), α-myosin, thyroid peroxidase (TPO), collagen, claudin 5+6, and S100B."
Vojdani A, Kharrazian D. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Clin Immunol. 2020 Aug;217:108480. doi: 10.1016/j.clim.2020.108480.
So could that mean that there is a transglutaminase-2-similar motif in Spike, similar enough to trigger autoantibodies against the real transglutaminase 2, and similar enough to form irreversible cross-linking in the giant fibrous clots that are being found?
Bird and Doorless Carp:
Thank you for your wonderful query and reply!
Honored to be the beneficiary of your efforts in sharing all of your scientific INFORMATION that I am trying my best to understand.
Bird, since your INFORMATION reflects your interest in HIV research, I am curious as to what you might think about this comment that I just read, that even the poster, investigative journalist, George Webb, conceded a need to be vetted:
"Wow, @dr_cottrell predicted five different binding sites for COVID in Feb 2020 including receptor CD-209. Guess what? The spike that binds to CD-209 also matches to CD-4, a key receptor in the downward path of HIV."
Happy holidays with thanks!
Hi Sally, thanks for pointing that out, I'd like to know more about that as well. I think Doorless Carp's answer would be a 40-page Review if we're lucky? I had an article started about CD-4/HIV but haven't gotten back to finish it. It seems that there are vulnerabilities to Spike being found in many if not all types of blood cells, white and red, including immature cells which are supposed to continually replenish our supply of fresh blood.
I'd like to see some data from hospitals on cell levels in all patients across the board, because from observation there are patients whose values are inexplicably waning. Combine those measurements with what we seem to be observing in acquaintances / in the news of common sicknesses hitting harder and longer. On the other hand, since these values are commonly tested in basic diagnostics, if there were a noticeable issue, it seems we would have heard more about it by now.
A topic with a lot of potential to look into. We'll have to all keep an eye on it.
Thank you so much for the kindness of your reply.
Oh, yes, wonderful Doorless Carp would write a tome!
And the fact that there are receptors. in addition to the omnipresent ACE2 receptor, facilitating the entrance of the spike in all type of white and red blood cells, gives me pause. I fear for all of us - especially cancer patients.
Thanks again!
Interesting point you raise there. I've looked into this further and coeliac disease generates the same antibodies.
This is not good as these correlate with elevated troponin & myocarditis in ACS cases.
Who needs CD when you can generate the same autoimmune antibodies via spike protein analogues?
It's the gift that keeps giving.
Antitissue transglutaminase antibodies in acute coronary syndrome: an alert signal of myocardial tissue lesion?
M Di Tola et al. J Intern Med. 2008 Jan.
https://pubmed.ncbi.nlm.nih.gov/18088251/
I haven't followed that path through about coeliac yet, but it did cross my mind to wonder what implications that could have for diet: would the cross-reactivity Spike --> Transglutaminase Antibody eventually also have potential to be amplified Gluten --> Transglutaminase Antibody; if so that presents an interesting situation for world rice- vs. wheat-producing nations. (This wouldn't be the case if the Spike-triggered antibody is against a different part of Transglutaminase, which I'm not sure if we know yet?)
There's also the fertility issue with TG antibodies.