Just got this one, but it is about a drug, synthetics, still interesting to notice that ROS pathway is extremely serious not only in ALS, it is from STAT (Cancer briefing), quote:
"Nuvalent says its ROS1-targeted drug shrank lung tumors in patients who failed other options
The company hopes its non-small cell lung cancer drug will be used where predecessors have not"
Further: "For 1% to 2% of patients with non-small cell lung cancer, tumors test positive for alterations in a gene called ROS1. ROS1-positive tumors often respond to one of five targeted therapies on the market, the first of which was approved in 2016 and the most recent of which was approved two weeks ago. "
It is about zidesamtinib, for people who 'like' drugs, in this case a brain-penetrant, TRK-sparing, highly selective ROS1 tyrosine kinase inhibitor (TKI) with activity against diverse ROS1 fusions and resistance mutations including G2032R. Just in this case it is to inhibit growth (cancer), whereby ALS is more about 'shrinking'... This info is from :
... Among patients with ROS1-positive NSCLC who received zidesamtinib at the RP2D, the most common treatment-emergent adverse effects (TEAEs) included peripheral edema (36%), constipation (17%), blood CPK increase (16%), fatigue (16%), and dyspnea (15%). Additionally, 10% of patients required dose reductions following TEAEs, and 2% discontinued therapy due to TEAEs.
I thought more about that Tyrosine kinase in ALS, as a target..
Once the cancer patients receive their medical linguistic curse called 'diagnosis' their objective thinking is gone. Equally with those victims participating in these trials you describe.. It is so depressive! Imagine they all could get completely well with enzymes, Vit's, ivermectin, liver supporting nutraceuticlas, etc., etc. Instead, they are mutating the rest of their left over stem cells towards stem cancer cells.. Thanks for the above list!
The problem with these sorts of engineered single-point drugs is recurrences due to mutations and cancer stem cells, not to mention possible loss of QoL for potentially little benefit. But they might be ok for some.
maybe to the list of supplementation one could add the SOD enzyme itself, lot of it?? That would help with the ROS formation.. Also when talking about Omega3's, the dose is essential.. In normal cases 1-2g/day should be enough, but in such a lethal case, doses of >>10x could be tried.. It is a pity that such fast annihilating disease is not known precisely for its missing physiological elements (minerals, like Mg, or maybe ATP, inhibition/binding/lack of specific neurotransmitters) or maybe some specific oral pathogenic bacteria, etc., etc.). Can never forget this guy, https://senate.universityofcalifornia.edu/in-memoriam/files/thomas-c-alber.html who knew so much, but not enough to safe his life!
Very good point. As with DNA testing, genetics Vs epigenetics, disease outcomes aren't that simple and there are many contributory factors you may investigate.
Autoimmune dysfunction and immune system priming is another huge part of many neurological disorders that receives scant attention.
What about methylated niacin instead of NAD+, just for the 30-40% of the population with MTHFR? I wish there were more studies in the overlap of MTHFR and its subsets with various autoimmune dysfunctions and cancer.
"Every baby in England is to have a DNA screening to avoid fatal diseases and receive personalised healthcare as part of the governmentâs ÂŁ650m investment in DNA technology, it has been reported."
Excuse me, but no. This is blatantly an attempt at datamining the genetics of every citizen in the UK by trying to adopt it retroactively. Fuck off with that bullshit about "fatal diseases"; the biggest fatal disease to human life is the UK government. No, you're not getting my family's genetics, bugger off!
Just got this one, but it is about a drug, synthetics, still interesting to notice that ROS pathway is extremely serious not only in ALS, it is from STAT (Cancer briefing), quote:
"Nuvalent says its ROS1-targeted drug shrank lung tumors in patients who failed other options
The company hopes its non-small cell lung cancer drug will be used where predecessors have not"
Further: "For 1% to 2% of patients with non-small cell lung cancer, tumors test positive for alterations in a gene called ROS1. ROS1-positive tumors often respond to one of five targeted therapies on the market, the first of which was approved in 2016 and the most recent of which was approved two weeks ago. "
It is about zidesamtinib, for people who 'like' drugs, in this case a brain-penetrant, TRK-sparing, highly selective ROS1 tyrosine kinase inhibitor (TKI) with activity against diverse ROS1 fusions and resistance mutations including G2032R. Just in this case it is to inhibit growth (cancer), whereby ALS is more about 'shrinking'... This info is from :
https://www.annalsofoncology.org/article/S0923-7534(24)02832-1/fulltext
with authors from institutions participating in covid19 'vaccines'... Problem, reaction, solution..???
... Among patients with ROS1-positive NSCLC who received zidesamtinib at the RP2D, the most common treatment-emergent adverse effects (TEAEs) included peripheral edema (36%), constipation (17%), blood CPK increase (16%), fatigue (16%), and dyspnea (15%). Additionally, 10% of patients required dose reductions following TEAEs, and 2% discontinued therapy due to TEAEs.
https://www.cancernetwork.com/view/zidesamtinib-may-yield-meaningful-outcomes-in-advanced-ros1-nsclc
I thought more about that Tyrosine kinase in ALS, as a target..
Once the cancer patients receive their medical linguistic curse called 'diagnosis' their objective thinking is gone. Equally with those victims participating in these trials you describe.. It is so depressive! Imagine they all could get completely well with enzymes, Vit's, ivermectin, liver supporting nutraceuticlas, etc., etc. Instead, they are mutating the rest of their left over stem cells towards stem cancer cells.. Thanks for the above list!
The problem with these sorts of engineered single-point drugs is recurrences due to mutations and cancer stem cells, not to mention possible loss of QoL for potentially little benefit. But they might be ok for some.
maybe to the list of supplementation one could add the SOD enzyme itself, lot of it?? That would help with the ROS formation.. Also when talking about Omega3's, the dose is essential.. In normal cases 1-2g/day should be enough, but in such a lethal case, doses of >>10x could be tried.. It is a pity that such fast annihilating disease is not known precisely for its missing physiological elements (minerals, like Mg, or maybe ATP, inhibition/binding/lack of specific neurotransmitters) or maybe some specific oral pathogenic bacteria, etc., etc.). Can never forget this guy, https://senate.universityofcalifornia.edu/in-memoriam/files/thomas-c-alber.html who knew so much, but not enough to safe his life!
Very good point. As with DNA testing, genetics Vs epigenetics, disease outcomes aren't that simple and there are many contributory factors you may investigate.
Autoimmune dysfunction and immune system priming is another huge part of many neurological disorders that receives scant attention.
What about methylated niacin instead of NAD+, just for the 30-40% of the population with MTHFR? I wish there were more studies in the overlap of MTHFR and its subsets with various autoimmune dysfunctions and cancer.
One of the reasons why universal folate injections and adulteration is bad practice.
the mod mRNA was known to decimate the innate immune system by definition, so the price to pay for it now is high, unfortunately...
ALS existed before SARS CoV 2 and the mRNA
Hey, so did Lou Gehrig, now you mention it .
Dang it, you've got me with that one.
So did murder; doesn't exonerate current and future criminals.
"Every baby in England is to have a DNA screening to avoid fatal diseases and receive personalised healthcare as part of the governmentâs ÂŁ650m investment in DNA technology, it has been reported."
Excuse me, but no. This is blatantly an attempt at datamining the genetics of every citizen in the UK by trying to adopt it retroactively. Fuck off with that bullshit about "fatal diseases"; the biggest fatal disease to human life is the UK government. No, you're not getting my family's genetics, bugger off!
Is the "is to have" going to be a legal "must " one wonders.
As ever follow the money - and as aptly illustrated by covidclown world - incompetent politicians.
( A thought just struck me when typing "incompetent". There really was no reason for me to have typed that).
If only Bechamp had prevailed over Pasteur.
If only the US had let Rockefeller keep Standard Oil ...
Itâs a real life GattacaâŚ
Yeah, get off my lawn with your pharma snake oils