I live in New Zealand and have a physician who has agreed to help me with an Ivermectin, doxycycline, lactoferrin protocol for metastasized prostate cancer, but the cost of Ivermectin here is out of this world. (Someone or some corporation is making a ton of money here with massive markup.) It costs me NZD $238 (USD $149) for thirty 3mg tabs, which is only one and half day's worth (for my body weight) of high-dose Ivermectin!!! I can't afford that. Do you have any contact info for a low-cost pharmacy in India that ships worldwide? I have the prescription necessary to get it through our Customs, but have heard so many stories of scams that I wouldn't know where to start to locate a legitimate exporter from India of 12mg Ivermectin tabs. Might you or your contacts know of one? Thanks.
Since that is a prescription product for pets in NZ, I doubt whether a veterinarian in NZ would be willing to put their license at risk by writing a "prescription" for a very large amount of Petmectin. Without a prescription, the shipment will be seized at the border.
That is a very strong combination, some people get great results from Fenbendazole too, just don't mix everything and go all in at max dose, although bovine lactoferin and ivermectin work very well together đđ
Doxy needs caution too, it may be cancer specific as it can damage the wrong mitochondria:
Doxycycline Promotes Carcinogenesis & Metastasis via Chronic Inflammatory Pathway: An In Vivo Approach
You've got a couple of options available, and I'm in exactly the same position in the UK. I can't recommend brands or dosing but you can buy equine paste a lot cheaper than tabs and the quality should be there if you go to the right source, I know someone with a phantom horse he needs to buy for!
For non cancer use I take berberine, although it does that too, or get subscribed to the cancer support group on Viber for advice on global supplies:
Thank you for your effort in making this compilation. It is very much appreciated. Happy to see Lactoferrin featured as I was harping about it in twitter from April 2020 onwards as a possible adjunct to C19 treatment but got no interaction whatsoever.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161750/#!po=10.6061). Apparently China was well aware of its benefit by placing mega-orders (1000 Tonnes!) from Australia very early on and so was Egypt who already had an Ivermectin/Lactoferrin protocol by April 2020. Lactoferrin seems as versatile a compound as Ivermectin.
When I read Lactoferrin cancer studies, some specify bLf (iron saturated LF) as opposed to apo-Lactoferrin but others donât. Nor any clarity regarding dosage. Reason I wonder is this: I pulled two people out of hospital because they clearly had anemia of inflammation and were about to be given iron and/or blood transfusions which could be fatal in such situations. I had ordered iron saturated LF from Italy (Lattoferrina) and that's what I gave them both. They both did extremely well and recovered normal hemoglobin values. So my question is if anybody knows: When it comes to cancer, does one lactoferrin have an advantage over another? It's practically impossible to find bLf from American supplement manufacturers.
My second comment is about Ivermectin and cancer. It's customary to assume that anti-oxidants are part of the cancer fight. But it seems taking them while using IVM as a cancer treatment negates IVM's benefit: "The presence of the mitochondrial fuel acetyl-L-carnitine (ALCAR), and the antioxidant N-acetyl-L-cysteine (NAC), could reverse IVM-induced inhibition." and other similar cautions appearing in several other IVM-Cancer studies: "Mechanism analysis showed that ivermectin promoted both total and mitochondrial ROS production in a dose-dependent manner, which could be eliminated by administering N-acetyl-l-cysteine (NAC) in CRC cells. Following NAC treatment, the inhibition of cell growth induced by ivermectin was reversed.â
So in order for IVM to be effective (and similar cautions appear in Fenbendazole Cancer studies) should one lay off ALL antioxidants? An exception seems to be high dose Intravenous Vitamin C which switches into a pro-oxidant that induces oxidative stress in cancer cells through the formation of cytotoxic levels of hydrogen peroxide. IV vit C however is out of the reach of most. Maybe an IVM cancer strategy could be similar to the Fenben protocol of 3 days on/4 days off with avoidance of any antioxidant supplements on those 3 days and resuming taking them on the remaining 4 days. Have no idea whether that would work and not end up interfering with IVMâs action. Just thinking aloud ;~)
Another view on Fenbendazole? DR. COLLEEN HUBER says so & I wrote on Fenbendazole as an anti-cancer therapeutic yet HUBER clarifies points that you should know! Balance is key & both sides, I find:
From the advice of AM Gonzalez I understand that bovine lactoferrin is the type with the highest efficacy, presumably it's a chelator with greater binding potential?
Regarding antioxidants, less an issue with that (most of our flavonoids are tumor suppressive but strongly antioxidant) the issue is multidrug resistance. NAC forces ROS out of the cell to protect the nucleus from the consequences of ACE2 binding by spike, but this also mediates multidrug resistance, so don't NAC or anything else without checking to see it's effects on MDR first. I think I listed some of them in my long Covid therapeutics Substack.
But yes the ROS aspect of IVM you would need to make sure that what you take with it is not working against you. It isn't always clearcut as most of our therapeutics are blocking multiple signalling pathways and the net effect may still be synergistic.
If in doubt, take IVM with LFN in isolation until you have solid data.
I don't consider anaemia but your Fe lactoferrin would be what I would research further.
Thanks. Seems like the safest course to take. My next foray is testing Lactoferrin as a pain killer. Very little info to be found. Nothing re dosage or upper safety limit. Here's the one study I found: https://pubmed.ncbi.nlm.nih.gov/34577568/ (Sorry about all 'deletes' -posted the wrong study and the delete button wouldn't work so pressed delete repeatedly repeatedly..but then it did in spades)
What a great study...a second benefit of interfering with the LRP receptors, the first being to reduce availability of ldl to cancer cells, I suspect. Another link between inflammation, pain and tumorigenesis. It's a warning signal for a reason.
Passionate about helping cancer patients, I am disseminating your article, with special interest in the extensive section on parasites and cancer, to two groups.Â
In the past two days, I feel so honored to be the beneficiary of such wonderful information from you, John Paul, and Jennifer Margulis.Â
Thank you Sally for your kind comments. The community trials group is seeing some excellent results, so there is hope, especially with co-benefits such as reversal of multidrug resistance.
Funny you mention a book as the original word doc was so long I had to add a contents page, which I've retained but obviously no page numbers!
Thanks Spiro. I did a search for ligands of streptonigrin and zinc, interesting:
The role of ring D in the antitumour antibiotic streptonigrin: metal complexation, DNA binding and topoisomerase inhibition by ABC ring analogues of streptonigrin
Would it help if someone sent it to you from the states in a different packaging?
I live in New Zealand and have a physician who has agreed to help me with an Ivermectin, doxycycline, lactoferrin protocol for metastasized prostate cancer, but the cost of Ivermectin here is out of this world. (Someone or some corporation is making a ton of money here with massive markup.) It costs me NZD $238 (USD $149) for thirty 3mg tabs, which is only one and half day's worth (for my body weight) of high-dose Ivermectin!!! I can't afford that. Do you have any contact info for a low-cost pharmacy in India that ships worldwide? I have the prescription necessary to get it through our Customs, but have heard so many stories of scams that I wouldn't know where to start to locate a legitimate exporter from India of 12mg Ivermectin tabs. Might you or your contacts know of one? Thanks.
https://www.virex.health/index.php?route=product%2Fproduct&product_id=53&utm_source=substack&utm_medium=email
Since that is a prescription product for pets in NZ, I doubt whether a veterinarian in NZ would be willing to put their license at risk by writing a "prescription" for a very large amount of Petmectin. Without a prescription, the shipment will be seized at the border.
That is a very strong combination, some people get great results from Fenbendazole too, just don't mix everything and go all in at max dose, although bovine lactoferin and ivermectin work very well together đđ
Doxy needs caution too, it may be cancer specific as it can damage the wrong mitochondria:
Doxycycline Promotes Carcinogenesis & Metastasis via Chronic Inflammatory Pathway: An In Vivo Approach
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801417/
You've got a couple of options available, and I'm in exactly the same position in the UK. I can't recommend brands or dosing but you can buy equine paste a lot cheaper than tabs and the quality should be there if you go to the right source, I know someone with a phantom horse he needs to buy for!
For non cancer use I take berberine, although it does that too, or get subscribed to the cancer support group on Viber for advice on global supplies:
https://doorlesscarp953.substack.com/p/a-prostate-community-trial
Thank you!
Synergistic pairing of ivermectin and fenbendazole found HIGHLY EFFECTIVE at preventing and treating cancer
https://www.2ndsmartestguyintheworld.com/p/synergistic-pairing-of-ivermectin
Nice work!
Just beautiful! Thank you for putting together all this work in such a great and organized format! All blessings to you!
Thank you, Doctor for your kind comments. I will certainly keep adding to the list.
Thank you for your effort in making this compilation. It is very much appreciated. Happy to see Lactoferrin featured as I was harping about it in twitter from April 2020 onwards as a possible adjunct to C19 treatment but got no interaction whatsoever.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161750/#!po=10.6061). Apparently China was well aware of its benefit by placing mega-orders (1000 Tonnes!) from Australia very early on and so was Egypt who already had an Ivermectin/Lactoferrin protocol by April 2020. Lactoferrin seems as versatile a compound as Ivermectin.
When I read Lactoferrin cancer studies, some specify bLf (iron saturated LF) as opposed to apo-Lactoferrin but others donât. Nor any clarity regarding dosage. Reason I wonder is this: I pulled two people out of hospital because they clearly had anemia of inflammation and were about to be given iron and/or blood transfusions which could be fatal in such situations. I had ordered iron saturated LF from Italy (Lattoferrina) and that's what I gave them both. They both did extremely well and recovered normal hemoglobin values. So my question is if anybody knows: When it comes to cancer, does one lactoferrin have an advantage over another? It's practically impossible to find bLf from American supplement manufacturers.
My second comment is about Ivermectin and cancer. It's customary to assume that anti-oxidants are part of the cancer fight. But it seems taking them while using IVM as a cancer treatment negates IVM's benefit: "The presence of the mitochondrial fuel acetyl-L-carnitine (ALCAR), and the antioxidant N-acetyl-L-cysteine (NAC), could reverse IVM-induced inhibition." and other similar cautions appearing in several other IVM-Cancer studies: "Mechanism analysis showed that ivermectin promoted both total and mitochondrial ROS production in a dose-dependent manner, which could be eliminated by administering N-acetyl-l-cysteine (NAC) in CRC cells. Following NAC treatment, the inhibition of cell growth induced by ivermectin was reversed.â
So in order for IVM to be effective (and similar cautions appear in Fenbendazole Cancer studies) should one lay off ALL antioxidants? An exception seems to be high dose Intravenous Vitamin C which switches into a pro-oxidant that induces oxidative stress in cancer cells through the formation of cytotoxic levels of hydrogen peroxide. IV vit C however is out of the reach of most. Maybe an IVM cancer strategy could be similar to the Fenben protocol of 3 days on/4 days off with avoidance of any antioxidant supplements on those 3 days and resuming taking them on the remaining 4 days. Have no idea whether that would work and not end up interfering with IVMâs action. Just thinking aloud ;~)
Very interesting info regarding NAC. Thanks for sharing! Also, I hadn't known about Lactoferrin before now.
Lactoferin+IVM has been effective as a last chance treatment at the end of the line when chemo has failed. And Fen + IVM as you say.
Good to know the other side of FenBen as well.
Another view on Fenbendazole? DR. COLLEEN HUBER says so & I wrote on Fenbendazole as an anti-cancer therapeutic yet HUBER clarifies points that you should know! Balance is key & both sides, I find:
https://palexander.substack.com/p/another-view-on-fenbendazole-dr-colleen?utm_source=post-email-title&publication_id=579356&post_id=138674943&utm_campaign=email-post-title&isFreemail=true&r=1d3rr3&utm_medium=email
Beautiful and well-thought out information. I appreciate your insight as it spurs one to read more extensively! Thank you!
Thank you for your long and detailed comment.
From the advice of AM Gonzalez I understand that bovine lactoferrin is the type with the highest efficacy, presumably it's a chelator with greater binding potential?
Regarding antioxidants, less an issue with that (most of our flavonoids are tumor suppressive but strongly antioxidant) the issue is multidrug resistance. NAC forces ROS out of the cell to protect the nucleus from the consequences of ACE2 binding by spike, but this also mediates multidrug resistance, so don't NAC or anything else without checking to see it's effects on MDR first. I think I listed some of them in my long Covid therapeutics Substack.
But yes the ROS aspect of IVM you would need to make sure that what you take with it is not working against you. It isn't always clearcut as most of our therapeutics are blocking multiple signalling pathways and the net effect may still be synergistic.
If in doubt, take IVM with LFN in isolation until you have solid data.
I don't consider anaemia but your Fe lactoferrin would be what I would research further.
Thanks. Seems like the safest course to take. My next foray is testing Lactoferrin as a pain killer. Very little info to be found. Nothing re dosage or upper safety limit. Here's the one study I found: https://pubmed.ncbi.nlm.nih.gov/34577568/ (Sorry about all 'deletes' -posted the wrong study and the delete button wouldn't work so pressed delete repeatedly repeatedly..but then it did in spades)
Haha no worries.
What a great study...a second benefit of interfering with the LRP receptors, the first being to reduce availability of ldl to cancer cells, I suspect. Another link between inflammation, pain and tumorigenesis. It's a warning signal for a reason.
Lots going on, so I forgot to say amazing deep dive, this one is quite brilliant !
Thank you, Doorless Carp!Â
A veritable tome!Â
Passionate about helping cancer patients, I am disseminating your article, with special interest in the extensive section on parasites and cancer, to two groups.Â
In the past two days, I feel so honored to be the beneficiary of such wonderful information from you, John Paul, and Jennifer Margulis.Â
https://hiddencomplexity.substack.com/p/chimeric-nature-of-galectin-3-and John Paul stated, "As a friend wrote, 'modulating Galectin-3 would be a good way to target cancer, hypothetically'. "
"https://jennifermargulis.substack.com/p/two-weeks-ago-i-saw-a-tumor-that?utm_source=profile&utm_medium=reader2 Increase in aggressive cancer
.Thanks you so much for your ever so valuable BOOK!
Thank you Sally for your kind comments. The community trials group is seeing some excellent results, so there is hope, especially with co-benefits such as reversal of multidrug resistance.
Funny you mention a book as the original word doc was so long I had to add a contents page, which I've retained but obviously no page numbers!
Thank you.
Hopefully life enhancing for many, if not life saving.
Awesome post.
What an extraordinary post! What a gift. Thank you. There is do much to digest.
Huge Thanks, I can offer some hope to others in need.
Expansive and elucidating reading, Carp. Thank you. Iâve sent it round to a friend with prostate cancer history. Much love. Mel
Thanks Mel. By all means get them to join the viber community trials group for support, the link is in the intro.
I sure will remind him of that.
Gosh, incredible library to save and reference - a mere thank you doesnât cover it!
100%!
Thanks. Will take a while to get through it all. God bless you for sharing.
Thanks Spiro. I did a search for ligands of streptonigrin and zinc, interesting:
The role of ring D in the antitumour antibiotic streptonigrin: metal complexation, DNA binding and topoisomerase inhibition by ABC ring analogues of streptonigrin
P I Anderberg et al. Anticancer Drug Des. 2001
https://pubmed.ncbi.nlm.nih.gov/11962512/#:~:text=interaction%20of%207-amino-2-%286%27-carboxy-2%27-pyridyl%29-6-methoxy-5%2C8-quinolinedione%2C%20an%20ABC%20ring%20analogue%20of,of%20DNA%20by%20topoisomerase%20II%2C%20has%20been%20studied.
I would need to do read a few papers on it to investigate further and see if tox issues have been addressed?