I would have to concur with these findings, and link to a pdf of 132 references is provided:
"How DMSO Naturally Eliminates Cancers
Analysis by A Midwestern Doctor"
"... In the first part of this series, I presented dozens of studies that show DMSO effectively treats cancer pain (which is often very challenging to address) and dramatically reduces many of the complications experienced from radiation therapy and chemotherapy (as it selectively protects healthy cells from those agents).
Given how debilitating each of those can be for a cancer patient, it is remarkable DMSO has not been adopted for any of those applications, particularly since addressing those does not take business from the cancer industry (and if anything would make more patients want to undergo conventional cancer care).
Note: 65% of oncologists' revenue comes from chemotherapy drugs3 (which coincidentally are by far the most profitable drug market4)."
I have a question about the use for OA/RA section. If I understood properly higher doses (over 5% DMSO) for prolonged periods were shown to weaken the cartilage and ligaments?
Thank you so much for compiling this. I ordered some DMSO & it arrived in a clear plastic bottle. I didnât have a brown bottle to decant it into so kept it in a dark cupboard. I read, in another Substack, that a 1:1 mix with castor oil is good to apply topically- but I was very disappointed to see my precious DMSO had set rock hard! (Exp 2027) Should I smash it up and compound the crystals and then mix the powder into my castor oil?
Castor oil shares many of DMSOs properties, such as absorption and it's anti-inflammatory effects. The two are said to work synergistically.
Most practitioners seem to apply the CO first and then apply diluted DMSO followed by a heat pack for 30 minutes (Not health advice, and I haven't tested this).
Assuming you have high purity CO and DMSO, it might be it needs melting with gentle heat, eg a water bath.
I will give that a go! Thank you so much for answering my question and for taking the time to compile this information and get it out to as many as possible. It is our best defence against the dark arts of the phHARMa wizards circle, haha
Eyes: 10% DMSO 2-4 x/day (no more eye infections, dry eyes, completely changed my eye health). Highly recommend for anyone with chronic eye issues.
Internal: 5 or 6 out of 7 days per week I start my day with a concoction that is not for the weak of heart. Fermented greens and fruit powder (Mercola), mushroom powders (Cordyceps, Turkey Tail, Reishi, Lionâs Mane, Maiittake, and one more I cannot remember right now), salt, methyne blue, liquid iodine, and 10 to 30 drops 99% DMSO. I take this with a magnesium complex, fermented beets. potassium, and ginko biloba. Sometimes I add pomegranate seed oil or black seed oil, but not often.
External: Depends on pain. I have chronic back pain. Sometimes 2x/day mixed with bio cold-presses castor oil or another clean fat-based carrier, sometimes magnesium oil.
Super tip for restless legs: I have mild restless legs that drive me crazy at night. Mix DMSO with magnesium and DMSO and high-quality lavender oil. Massage calves. Amazing!
Efficiency of osmotic and chemical treatments to improve the permeation of the cryoprotectant dimethyl sulfoxide to Japanese whiting (Sillago japonica) embryos
Sk M Rahman et al. Theriogenology. 2011.
... Incorporation of DMSO into the embryos was enhanced by 143-170% in the presence of 0.25 M MgCl(2) and 0.125 M CaCl(2) compared to sea water. A combination of treatments with trehalose and MgCl(2) was even more effective in promoting DMSO permeation (191% compared to untreated embryos).
But the problem is that there is no definitive list of drugs it may interact with, and in what way. The studies have never been done, you are on your own.
This is why medical supervision is highly recommended.
"Another problem with clinical testing is that its main side-effect, garlic-smelling breath, makes double-blind experiments difficult, because the patients (and doctors) can always tell who had been given DMSO and who had the placebo!"
...Just make the placebo garlic. Or develop a placebo whose sole purpose is a long-last garlic breath smell if garlic itself is too much of an active substance. The sheer laziness in refusing testing to come up with such a simple solution is mind blowing.
"Results were similar in beagles; in humans, it only took 5 minutes to enter the blood, levels plateaued for 4-6 hours, but remained elevated and almost unchanged for 1 1/2 to 3 days."
Why does everything give me superweapon-bioweapon vibes?
"For example skin contact with DMSO and a cyanide salt would pose a high risk of cyanide poisoning."
Sounds like a CIA invention. Didn't they invent a "heart attack gun" at one point?
"You send in a blood sample so that your DNA can be profiled."
"Your demographic profile is considered, and a software medic âdiagnosesâ you. "
You can blame me for that (not the genetic bit), and I mean literally. When I was working in the NHS, before I became disabled pre-pandemic, I had proposed - and was actively working on - a blood form that could identify early warning signals; it was going to use algorithms designed by myself and verified by a clinician (there was a disturbing trend where things were deferred to my judgement!). There's no sampling of DNA involved, but I wouldn't put it beyond them to have some scumbag tack in datamining.
Before I left, I actually argued for GPT 3 to act as - and again, I stress this - *warning light* (not a diagnostic feature, but an alert notification for someone qualified to verify/double-check). The idea would be anonymise the data and 'keep it simple stupid'; GPT wouldn't have the foggiest whose blood data we were submitting, just it needed to determine if there were any health issues from the data given.
So think of it like a passively monitoring AI triage system where patients who suddenly start to deteriorate flag an alert for symptoms that would otherwise be missed by overworked staff. I had to quit work before it could be implemented and I genuinely think it would have improved the patient experience. Now we've got these 'let *only* the AI diagnose it' shitty ideas which is not what the original vision was: the AI was supposed to be an alert tool for clinicians, not a diagnostic tool for patients.
GPT has massively improved since that last proposal, but I still would not trust it in isolation. There has to be checks and balances.
"the FDA has refused seven applications to conduct clinical studies, and approved only 2"
Is this because they're concerned that even with the lens distortion drawbacks, that DSMO could undercut the bottom line of pharma companies so they've been told to put the kibosh on DSMO?
The idea it can be used to help a chemical bypass the skin is a double-edged sword, but one I think still has useful applications if used carefully. FDA resistance to it despite approving toxic mRNA shots seems mightily suspicious and I don't think they're doing it with our health in mind.
Interesting points, agreed. I have nothing against genetic profiling or using AI as a heads-up to potential problems, or your idea of looking for trend changes in your sample. The problem we have, though, is the intentions of the politicians pushing this stuff out. Our health isn't the priority, we know that all too well.
After what happened, still without any admission of guilt or consequences, your default response has to be suspicion and rejection of anything they push on you, until proven safe and genuinely effective over a long period.
Oh, I'm personally against genetic profiling, and the system was never designed for that. It was simply an "intelligent" blood form that passively would spot changes and flag them; ideally merging a dataset of known, evidenced conditions indicated by certain changes.
Did you know there's almost no literature on what the upper bounds of a blood result should be? Obviously 0 of anything is the lowest, but I found it incredulous there's no "impossible big number"; I wanted to protect against human error (accidental keyboard number slide, etc), but crazily no-one has ever done the calculations for what counts as an oversaturation point that physically the human body cannot have (I.E. if the blood was 100% pure urea what is the maximum concentration expressed as mmol?).
Similarly there's almost no data on what should be physically impossible to have absent from the blood; and if so, what the absolute minimum should be. There's again no data on E.G. the lowest realistic/possible blood pressure count, whilst every clinician I queried agreed 50 over 60 would be insanely low, as one commented 'if there's still pressure then surely the heart is still beating and therefore the patient is still alive?'.
"The problem we have, though, is the intentions of the politicians pushing this stuff out."
I wouldn't trust most of the staff in the NHS either. It wavers between outright incompetence, indifference, to downright wanton disregard and malice. You'll be pleased to know not a single organisation has come to close to what I was working on in the last 6 years, and I've only heard of one early warning system being deployed and it was disappointingly bad - it was only concerned with SP02 and pulse, arguably the lowest of low in terms of hurdles.
While cautionary advice should be heeded in the use of any medication, it should be noted that pharmaceutical grade and uncontaminated DMSO for human use is widely available from legitimate sources and reputable companies; one needn't visit your local hardware store.
In the states maybe, here in Greece Europe I found only one gel with minimal concentration (30%). Went for the chemist e shop for 99,8%, which said in label it had some trace elements , most notorious lead at 0,00001%. I am perplexed
It seems to need attention of the possible accomplishment other than the low-concentrated application to ectoderm system. We should have a doctor able in total who included it manage the endoblast.
Due to their size, Spike would not be able to penetrate nanopores, but as DMSO seems to make different lipophilic membranes more permeable, it could facilitate the passage of LNPs. Good question!
Quick check:
This was with reference to manufacturing LNPs, but it affects their properties.
"Choice of organic solvent affects function of mRNA-LNP; pyridine produces highly functional mRNA-LNP" (30th March 2025)
"3.2. Organic solvent dissolving lipid has influence on the mRNA transfection efficiency of mRNA-LNPs
We evaluated the in vitro function of the mRNA-LNPs prepared using various organic solvents. fLuc-coding mRNA-LNPs prepared using a series of organic solvents were added to A549 and HepG2 cells, and the expression levels of fLuc were measured. Compared to ethanol, methanol, 2-propanol, acetonitrile, DMF, DMSO, and acetone, pyridine showed higher fLuc expression (Fig. 1).
... We first demonstrated that the properties of mRNA-LNPs were affected by the organic solvent that dissolved the lipids in the preparation of mRNA-LNPs by the solvent dilution method. The screening results showed that pyridine improved the quality and function of mRNA-LNPs in vitro, and its usefulness was confirmed in vivo. "
I would have to concur with these findings, and link to a pdf of 132 references is provided:
"How DMSO Naturally Eliminates Cancers
Analysis by A Midwestern Doctor"
"... In the first part of this series, I presented dozens of studies that show DMSO effectively treats cancer pain (which is often very challenging to address) and dramatically reduces many of the complications experienced from radiation therapy and chemotherapy (as it selectively protects healthy cells from those agents).
Given how debilitating each of those can be for a cancer patient, it is remarkable DMSO has not been adopted for any of those applications, particularly since addressing those does not take business from the cancer industry (and if anything would make more patients want to undergo conventional cancer care).
Note: 65% of oncologists' revenue comes from chemotherapy drugs3 (which coincidentally are by far the most profitable drug market4)."
https://articles.mercola.com/sites/articles/archive/2025/04/18/how-dmso-naturally-eliminates-cancers.aspx
Thanks for the in depth investigation of DMSO.
I have a question about the use for OA/RA section. If I understood properly higher doses (over 5% DMSO) for prolonged periods were shown to weaken the cartilage and ligaments?
Was that the takeaway?
It's something to be aware of, especially if you take it at high doses long term.
Another study:
Effect of Dimethylsulfoxide on Articular Cartilage Proteoglycan Synthesis and Degradation, Chondrocyte Viability, and Matrix Water Content (2008)
"... ConclusionsâDMSO, in relatively low concentration, is detrimental to articular cartilage."
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1532-950X.1998.tb00153.x
Thank you so much for compiling this. I ordered some DMSO & it arrived in a clear plastic bottle. I didnât have a brown bottle to decant it into so kept it in a dark cupboard. I read, in another Substack, that a 1:1 mix with castor oil is good to apply topically- but I was very disappointed to see my precious DMSO had set rock hard! (Exp 2027) Should I smash it up and compound the crystals and then mix the powder into my castor oil?
Or throw the whole bottle away and start over?
Is William following you?
Not an endorsement, paywalled, but timely:
DMSO / CASTOR Oil Eye Drops Testimonials - Vision Problems Successfully Treated - 11 short and fascinating Testimonials!
https://makismd.substack.com/p/dmso-castor-oil-eye-drops-testimonials
Castor oil shares many of DMSOs properties, such as absorption and it's anti-inflammatory effects. The two are said to work synergistically.
Most practitioners seem to apply the CO first and then apply diluted DMSO followed by a heat pack for 30 minutes (Not health advice, and I haven't tested this).
Assuming you have high purity CO and DMSO, it might be it needs melting with gentle heat, eg a water bath.
I will give that a go! Thank you so much for answering my question and for taking the time to compile this information and get it out to as many as possible. It is our best defence against the dark arts of the phHARMa wizards circle, haha
Btw I've just ordered some castor oil.
It has antiinflammatory effects similar to those from hot chillis.
***
Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin
https://pubmed.ncbi.nlm.nih.gov/11534859/
Two years taking DMSO. It is pretty amazing. However, it is good to be cautious with something so powerful. Thanks for the deep dive!
đ Out of interest, do you mind me asking what dose you take, and how do you take it? Thanks.
Sure!
All pharmaceutical grade.
Eyes: 10% DMSO 2-4 x/day (no more eye infections, dry eyes, completely changed my eye health). Highly recommend for anyone with chronic eye issues.
Internal: 5 or 6 out of 7 days per week I start my day with a concoction that is not for the weak of heart. Fermented greens and fruit powder (Mercola), mushroom powders (Cordyceps, Turkey Tail, Reishi, Lionâs Mane, Maiittake, and one more I cannot remember right now), salt, methyne blue, liquid iodine, and 10 to 30 drops 99% DMSO. I take this with a magnesium complex, fermented beets. potassium, and ginko biloba. Sometimes I add pomegranate seed oil or black seed oil, but not often.
External: Depends on pain. I have chronic back pain. Sometimes 2x/day mixed with bio cold-presses castor oil or another clean fat-based carrier, sometimes magnesium oil.
Super tip for restless legs: I have mild restless legs that drive me crazy at night. Mix DMSO with magnesium and DMSO and high-quality lavender oil. Massage calves. Amazing!
Thanks! I used magnesium oil at full saturation. I need to see if there are any studies of combination therapies with DMSO, it could be a wild ride.
When used as a cryoprotectant:
Efficiency of osmotic and chemical treatments to improve the permeation of the cryoprotectant dimethyl sulfoxide to Japanese whiting (Sillago japonica) embryos
Sk M Rahman et al. Theriogenology. 2011.
... Incorporation of DMSO into the embryos was enhanced by 143-170% in the presence of 0.25 M MgCl(2) and 0.125 M CaCl(2) compared to sea water. A combination of treatments with trehalose and MgCl(2) was even more effective in promoting DMSO permeation (191% compared to untreated embryos).
https://pubmed.ncbi.nlm.nih.gov/20961605/
đđťđđť
Who should NOT take dmso? For instance one on blood thinners? Or other drugs? I have never seen a list.
I list a few in this section, taken from Plumb's:
https://doorlesscarp953.substack.com/p/just-say-dmso?open=false#%C2%A7in-veterinary-medicine
But the problem is that there is no definitive list of drugs it may interact with, and in what way. The studies have never been done, you are on your own.
This is why medical supervision is highly recommended.
Anyway to get a link that opens the different chapters?
Thanks!
https://shorturl.at/uDNzd
Thanks for shortcut link!.. Must be my mobile, as I am unable to get anything but a blank page with it đ¤ˇââď¸
the DMSO handbook for doctors
Long link:
https://www.google.co.uk/url?sa=t&source=web&rct=j&opi=89978449&url=https://www.eden-shop.eu/wp-content/uploads/2020/06/Scott-Archie-DMSO-Handbook.pdf&ved=2ahUKEwj1i5XjkoyNAxWYAHkGHX2zJpcQFnoECDQQAQ&usg=AOvVaw2zfo00JU4gn83-WTf7n1vG
Very interesting. Thanks for the immersion into this therapeutic. I am reposting on my SS.
Thank you for sharing and raising awareness.
Thank you for such a thorough and balanced review.
most importantly, to be administered under expert guidance for dosing.
"Another problem with clinical testing is that its main side-effect, garlic-smelling breath, makes double-blind experiments difficult, because the patients (and doctors) can always tell who had been given DMSO and who had the placebo!"
...Just make the placebo garlic. Or develop a placebo whose sole purpose is a long-last garlic breath smell if garlic itself is too much of an active substance. The sheer laziness in refusing testing to come up with such a simple solution is mind blowing.
"Results were similar in beagles; in humans, it only took 5 minutes to enter the blood, levels plateaued for 4-6 hours, but remained elevated and almost unchanged for 1 1/2 to 3 days."
Why does everything give me superweapon-bioweapon vibes?
"For example skin contact with DMSO and a cyanide salt would pose a high risk of cyanide poisoning."
Sounds like a CIA invention. Didn't they invent a "heart attack gun" at one point?
"You send in a blood sample so that your DNA can be profiled."
"Your demographic profile is considered, and a software medic âdiagnosesâ you. "
You can blame me for that (not the genetic bit), and I mean literally. When I was working in the NHS, before I became disabled pre-pandemic, I had proposed - and was actively working on - a blood form that could identify early warning signals; it was going to use algorithms designed by myself and verified by a clinician (there was a disturbing trend where things were deferred to my judgement!). There's no sampling of DNA involved, but I wouldn't put it beyond them to have some scumbag tack in datamining.
Before I left, I actually argued for GPT 3 to act as - and again, I stress this - *warning light* (not a diagnostic feature, but an alert notification for someone qualified to verify/double-check). The idea would be anonymise the data and 'keep it simple stupid'; GPT wouldn't have the foggiest whose blood data we were submitting, just it needed to determine if there were any health issues from the data given.
So think of it like a passively monitoring AI triage system where patients who suddenly start to deteriorate flag an alert for symptoms that would otherwise be missed by overworked staff. I had to quit work before it could be implemented and I genuinely think it would have improved the patient experience. Now we've got these 'let *only* the AI diagnose it' shitty ideas which is not what the original vision was: the AI was supposed to be an alert tool for clinicians, not a diagnostic tool for patients.
GPT has massively improved since that last proposal, but I still would not trust it in isolation. There has to be checks and balances.
"the FDA has refused seven applications to conduct clinical studies, and approved only 2"
Is this because they're concerned that even with the lens distortion drawbacks, that DSMO could undercut the bottom line of pharma companies so they've been told to put the kibosh on DSMO?
The idea it can be used to help a chemical bypass the skin is a double-edged sword, but one I think still has useful applications if used carefully. FDA resistance to it despite approving toxic mRNA shots seems mightily suspicious and I don't think they're doing it with our health in mind.
Interesting points, agreed. I have nothing against genetic profiling or using AI as a heads-up to potential problems, or your idea of looking for trend changes in your sample. The problem we have, though, is the intentions of the politicians pushing this stuff out. Our health isn't the priority, we know that all too well.
After what happened, still without any admission of guilt or consequences, your default response has to be suspicion and rejection of anything they push on you, until proven safe and genuinely effective over a long period.
Oh, I'm personally against genetic profiling, and the system was never designed for that. It was simply an "intelligent" blood form that passively would spot changes and flag them; ideally merging a dataset of known, evidenced conditions indicated by certain changes.
Did you know there's almost no literature on what the upper bounds of a blood result should be? Obviously 0 of anything is the lowest, but I found it incredulous there's no "impossible big number"; I wanted to protect against human error (accidental keyboard number slide, etc), but crazily no-one has ever done the calculations for what counts as an oversaturation point that physically the human body cannot have (I.E. if the blood was 100% pure urea what is the maximum concentration expressed as mmol?).
Similarly there's almost no data on what should be physically impossible to have absent from the blood; and if so, what the absolute minimum should be. There's again no data on E.G. the lowest realistic/possible blood pressure count, whilst every clinician I queried agreed 50 over 60 would be insanely low, as one commented 'if there's still pressure then surely the heart is still beating and therefore the patient is still alive?'.
"The problem we have, though, is the intentions of the politicians pushing this stuff out."
I wouldn't trust most of the staff in the NHS either. It wavers between outright incompetence, indifference, to downright wanton disregard and malice. You'll be pleased to know not a single organisation has come to close to what I was working on in the last 6 years, and I've only heard of one early warning system being deployed and it was disappointingly bad - it was only concerned with SP02 and pulse, arguably the lowest of low in terms of hurdles.
While cautionary advice should be heeded in the use of any medication, it should be noted that pharmaceutical grade and uncontaminated DMSO for human use is widely available from legitimate sources and reputable companies; one needn't visit your local hardware store.
In the states maybe, here in Greece Europe I found only one gel with minimal concentration (30%). Went for the chemist e shop for 99,8%, which said in label it had some trace elements , most notorious lead at 0,00001%. I am perplexed
Terrific. I am only half way through. I appreciate this post very much.
thanks for sharing I will ad a bit more about DMSO later
Holy Moly.. such a well written stackâŚmind now blown⌠that half life is interesting.
It seems to need attention of the possible accomplishment other than the low-concentrated application to ectoderm system. We should have a doctor able in total who included it manage the endoblast.
Thank you for your splendid report.
would dmso facilitate the transport of spike protein throught the body????
I have wondered about this as well
Due to their size, Spike would not be able to penetrate nanopores, but as DMSO seems to make different lipophilic membranes more permeable, it could facilitate the passage of LNPs. Good question!
Quick check:
This was with reference to manufacturing LNPs, but it affects their properties.
"Choice of organic solvent affects function of mRNA-LNP; pyridine produces highly functional mRNA-LNP" (30th March 2025)
"3.2. Organic solvent dissolving lipid has influence on the mRNA transfection efficiency of mRNA-LNPs
We evaluated the in vitro function of the mRNA-LNPs prepared using various organic solvents. fLuc-coding mRNA-LNPs prepared using a series of organic solvents were added to A549 and HepG2 cells, and the expression levels of fLuc were measured. Compared to ethanol, methanol, 2-propanol, acetonitrile, DMF, DMSO, and acetone, pyridine showed higher fLuc expression (Fig. 1).
... We first demonstrated that the properties of mRNA-LNPs were affected by the organic solvent that dissolved the lipids in the preparation of mRNA-LNPs by the solvent dilution method. The screening results showed that pyridine improved the quality and function of mRNA-LNPs in vitro, and its usefulness was confirmed in vivo. "
https://www.sciencedirect.com/science/article/pii/S0378517325002030